Abstract
We have evaluated the impact of the CCAAT enhancer-binding protein (C/EBP) transcription factors on human papillomavirus type 11 (HPV11). C/EBPβ is in nuclei of cultured foreskin keratinocytes and hinds its consensus sequence in HPV11 DNA. We have used the novel approach of depleting the availability of C/EBPs in vivo using nuclease-resistant oligomers containing C/EBP DNA binding sites. In cultured foreskin keratinocytes containing replicating HPV11 DNA, levels of both HPV11 transcripts and HPV DNA increase after treatment with oligomers containing the C/EBPβ DNA binding motif. These results indicate that C/EBPβ is a repressor for HPV11 in keratinocytes.
Original language | English (US) |
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Pages (from-to) | 4839-4844 |
Number of pages | 6 |
Journal | Journal of virology |
Volume | 70 |
Issue number | 7 |
DOIs | |
State | Published - 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology