CD8+ regulatory T cells in persistent human viral infections

Eva K. Billerbeck, Robert Thimme

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Regulatory T cells (Treg cells) play an important role in the regulation and suppression of immune responses to self- and foreign antigens. Suppressed and impaired host immune responses are a major characteristic of many persistent human virus infections, such as those caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), and herpes virus. It has recently become evident that immune regulation mediated by Treg cells may comprise one mechanism that contributes to the impairment of virus-specific immune responses. Indeed, during viral infection, the generation of distinct subsets of CD4+ as well as CD8+ Treg cells has been reported. The phenotypic and functional heterogeneity of Treg cell subsets involved in the suppression of virus-specific immune responses suggests that different mechanisms and factors contribute to the generation of those cells during viral infection. This review focuses on the CD8+ Treg cell subset and summarizes current knowledge about the induction and function of CD8+ Treg cells in persistent human virus infections.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalHuman Immunology
Volume69
Issue number11
DOIs
StatePublished - Nov 1 2008
Externally publishedYes

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Virus Diseases
Regulatory T-Lymphocytes
Viruses
Autoantigens
Hepacivirus
HIV

Keywords

  • CD8+ regulatory T cells
  • HCV
  • HIV
  • Immune suppression
  • Viral infection

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

CD8+ regulatory T cells in persistent human viral infections. / Billerbeck, Eva K.; Thimme, Robert.

In: Human Immunology, Vol. 69, No. 11, 01.11.2008, p. 771-775.

Research output: Contribution to journalArticle

Billerbeck, Eva K. ; Thimme, Robert. / CD8+ regulatory T cells in persistent human viral infections. In: Human Immunology. 2008 ; Vol. 69, No. 11. pp. 771-775.
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