CD57 (leu-7) Expression is helpful in diagnosis of the follicular variant of papillary thyroid carcinoma

Ashraf Khan, Stephen P. Baker, Nilima A. Patwardhan, James M. Pullman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

CD57 (HNK-1) is a oligosaccharide antigen that is expressed by cells of several lineages. It is present on multipotential neuroepithelial cells during embryogenesis, and tumours of epithelial, neuroectodermal and nerve sheath origin also express CD57. Its role in the diagnosis of thyroid tumours is controversial. We have studied CD57 expression by immunohistochemistry to determine its utility in the classification of thyroid follicular lesions. Study material included 114 normal thyroid sections, 77 benign thyroid lesions (29 colloid nodules, 22 follicular adenomas, 20 cases of Hashimoto's thyroiditis and 6 of Grave's disease) and 83 thyroid carcinomas, including 31 follicular variants of papillary carcinoma. We observed CD57 positivity in 95% of thyroid carcinomas, 27% of follicular adenomas and 10% of colloid nodules. It was not expressed in the normal thyroid. CD57 expression in thyroid carcinomas was significantly different from that in normal and benign thyroid lesions (P < 0.0001). The follicular variant of papillary thyroid carcinoma also showed significantly higher CD57 expression than colloid nodules (P < 0.0009) or follicular adenomas (P < 0.0009). No significant difference was seen between colloid nodules and follicular adenomas. We conclude that CD57 immunohistochemistry is valuable in the classification of thyroid follicular lesions into benign and malignant groups and is also helpful in the diagnosis of the follicular variant of papillary thyroid carcinoma.

Original languageEnglish (US)
Pages (from-to)427-432
Number of pages6
JournalVirchows Archiv
Volume432
Issue number5
DOIs
StatePublished - 1998
Externally publishedYes

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Thyroid Gland
Colloids
Adenoma
Thyroid Neoplasms
Immunohistochemistry
Neuroectodermal Tumors
Carcinoma, Papillary, Follicular
Neuroepithelial Cells
Hashimoto Disease
Graves Disease
Cell Lineage
Papillary Thyroid cancer
Oligosaccharides
Embryonic Development
Antigens
Neoplasms

Keywords

  • CD57 (Leu-7)
  • Follicular variant of papillary carcinoma
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

CD57 (leu-7) Expression is helpful in diagnosis of the follicular variant of papillary thyroid carcinoma. / Khan, Ashraf; Baker, Stephen P.; Patwardhan, Nilima A.; Pullman, James M.

In: Virchows Archiv, Vol. 432, No. 5, 1998, p. 427-432.

Research output: Contribution to journalArticle

Khan, Ashraf ; Baker, Stephen P. ; Patwardhan, Nilima A. ; Pullman, James M. / CD57 (leu-7) Expression is helpful in diagnosis of the follicular variant of papillary thyroid carcinoma. In: Virchows Archiv. 1998 ; Vol. 432, No. 5. pp. 427-432.
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