CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

Lilianne Barbar, Tanya Jain, Matthew Zimmer, Ilya Kruglikov, Jessica S. Sadick, Minghui Wang, Kriti Kalpana, Indigo V.L. Rose, Suzanne R. Burstein, Tomasz Rusielewicz, Madhura Nijsure, Kevin A. Guttenplan, Angelique di Domenico, Gist Croft, Bin Zhang, Hiroko Nobuta, Jean M. Hébert, Shane A. Liddelow, Valentina Fossati

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Barbar et al. identify CD49f as a novel surface marker expressed by human astrocytes that can purify hiPSC-astrocytes and primary fetal astrocytes. CD49f+ hiPSC-astrocytes respond to pro-inflammatory stimuli and become A1 reactive astrocytes, which are dysfunctional and secrete neurotoxic factors that induce apoptosis in human and rodent neurons.

Original languageEnglish (US)
Pages (from-to)436-453.e12
JournalNeuron
Volume107
Issue number3
DOIs
StatePublished - Aug 5 2020

Keywords

  • A1 reactive astrocytes
  • CD49f
  • FACS purification
  • astrocytes
  • induced pluripotent stem cells
  • neurodegeneration
  • neurotoxicity

ASJC Scopus subject areas

  • Neuroscience(all)

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