CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis

Melissa A. Cosenza-Nashat, Mee Ohk Kim, Meng Liang Zhao, Hyeon Sook Suh, Sunhee C. Lee

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

CD45 is a membrane tyrosine phosphatase that modulates the function of the hematopoietic cells. In vitro, agonist antibodies to CD45RO or CD45RB isoforms have been shown to suppress microglial activation, but whether microglia in vivo express these isoforms in HIV encephalitis (HIVE) is unknown. Brain sections from control and HIVE were immunostained for CD45 isoforms using exon-specific antibodies (RA, RB, RC and RO). RA and RC were limited to rare lymphocytes, while RB expression was robust in microglia and inflammatory cells. RO was low in control microglia, but increased in HIVE. RO was also localized to macrophages and CD8+ T cells. Targeting CD45 in vivo with isoform-specific antibodies remains a therapeutic option for neuroinflammatory diseases.

Original languageEnglish (US)
Pages (from-to)256-265
Number of pages10
JournalBrain Pathology
Volume16
Issue number4
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

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    Cosenza-Nashat, M. A., Kim, M. O., Zhao, M. L., Suh, H. S., & Lee, S. C. (2006). CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis. Brain Pathology, 16(4), 256-265. https://doi.org/10.1111/j.1750-3639.2006.00027.x