CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis

Pooja Arora, Erin L. Foster, Steven A. Porcelli

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Scopus citations

Abstract

The critical role of peptide antigen-specific T cells in controlling mycobacterial infections is well documented in natural resistance and vaccineinduced immunity against Mycobacterium Tuberculosis. However, many other populations of leukocytes contribute to innate and adaptive immunity against mycobacteria. Among these, non-conventional T cells recognizing lipid antigens presented by the CD1 antigen presentation system have attracted particular interest. In this chapter, we review the basic immunobiology and potential antimycobacterial properties of a subset of CD1-restricted T cells that have come to be known as Natural Killer T cells. This group of lipid reactive T cells is notable for its high level of conservation between humans and mice, thus enabling a wide range of highly informative studies in mouse models. As reviewed below, NKT cells appear to have subtle but potentially significant activities in the host response to mycobacteria. Importantly, they also provide a framework for investigations into other types of lipid antigen-specific T cells that may be more abundant in larger mammals such as humans.

Original languageEnglish (US)
Title of host publicationThe New Paradigm of Immunity to Tuberculosis
PublisherSpringer New York LLC
Pages199-223
Number of pages25
ISBN (Print)9781461461104
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume783
ISSN (Print)0065-2598

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Keywords

  • Apolipoprotein E (ApoE)
  • CD1D1 genes
  • CD1d expression
  • Cortical thymocytes
  • Glycolipids
  • Invariant NKT (iNKT) cells
  • Macrophages
  • Mammalian major histocompatibility complex (MHC) class I proteins
  • Microsomal triglyceride transfer protein (MTP)
  • Mycobacterium Tuberculosis
  • Mycobacterium bovis BCG
  • Natural killer T (NKT) cells
  • Niemann-pick type C2 (NPC2) protein
  • Saposin family (saposins AD)
  • T cell antigen receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Arora, P., Foster, E. L., & Porcelli, S. A. (2013). CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis. In The New Paradigm of Immunity to Tuberculosis (pp. 199-223). (Advances in Experimental Medicine and Biology; Vol. 783). Springer New York LLC. https://doi.org/10.1007/978-1-4614-6111-1_11