CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis

Pooja Arora, Erin L. Foster, Steven A. Porcelli

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

The critical role of peptide antigen-specific T cells in controlling mycobacterial infections is well documented in natural resistance and vaccineinduced immunity against Mycobacterium Tuberculosis. However, many other populations of leukocytes contribute to innate and adaptive immunity against mycobacteria. Among these, non-conventional T cells recognizing lipid antigens presented by the CD1 antigen presentation system have attracted particular interest. In this chapter, we review the basic immunobiology and potential antimycobacterial properties of a subset of CD1-restricted T cells that have come to be known as Natural Killer T cells. This group of lipid reactive T cells is notable for its high level of conservation between humans and mice, thus enabling a wide range of highly informative studies in mouse models. As reviewed below, NKT cells appear to have subtle but potentially significant activities in the host response to mycobacteria. Importantly, they also provide a framework for investigations into other types of lipid antigen-specific T cells that may be more abundant in larger mammals such as humans.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages199-223
Number of pages25
Volume783
ISBN (Print)9781461461104
DOIs
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume783
ISSN (Print)00652598

Fingerprint

Natural Killer T-Cells
T-cells
Mycobacterium tuberculosis
Immunity
T-Lymphocytes
Mycobacterium
Lipids
Antigens
Innate Immunity
CD1 Antigens
Antigen Presentation
Adaptive Immunity
Mammals
Leukocytes
Conservation
Peptides
Infection
Population

Keywords

  • Apolipoprotein E (ApoE)
  • CD1d expression
  • CD1D1 genes
  • Cortical thymocytes
  • Glycolipids
  • Invariant NKT (iNKT) cells
  • Macrophages
  • Mammalian major histocompatibility complex (MHC) class I proteins
  • Microsomal triglyceride transfer protein (MTP)
  • Mycobacterium bovis BCG
  • Mycobacterium Tuberculosis
  • Natural killer T (NKT) cells
  • Niemann-pick type C2 (NPC2) protein
  • Saposin family (saposins AD)
  • T cell antigen receptors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Arora, P., Foster, E. L., & Porcelli, S. A. (2013). CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis. In Advances in Experimental Medicine and Biology (Vol. 783, pp. 199-223). (Advances in Experimental Medicine and Biology; Vol. 783). Springer New York LLC. https://doi.org/10.1007/978-1-4614-6111-1_11

CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis. / Arora, Pooja; Foster, Erin L.; Porcelli, Steven A.

Advances in Experimental Medicine and Biology. Vol. 783 Springer New York LLC, 2013. p. 199-223 (Advances in Experimental Medicine and Biology; Vol. 783).

Research output: Chapter in Book/Report/Conference proceedingChapter

Arora, P, Foster, EL & Porcelli, SA 2013, CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis. in Advances in Experimental Medicine and Biology. vol. 783, Advances in Experimental Medicine and Biology, vol. 783, Springer New York LLC, pp. 199-223. https://doi.org/10.1007/978-1-4614-6111-1_11
Arora P, Foster EL, Porcelli SA. CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis. In Advances in Experimental Medicine and Biology. Vol. 783. Springer New York LLC. 2013. p. 199-223. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-6111-1_11
Arora, Pooja ; Foster, Erin L. ; Porcelli, Steven A. / CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis. Advances in Experimental Medicine and Biology. Vol. 783 Springer New York LLC, 2013. pp. 199-223 (Advances in Experimental Medicine and Biology).
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