TY - CHAP
T1 - CD1d and natural killer T cells in immunity to mycobacterium Tuberculosis
AU - Arora, Pooja
AU - Foster, Erin L.
AU - Porcelli, Steven A.
PY - 2013
Y1 - 2013
N2 - The critical role of peptide antigen-specific T cells in controlling mycobacterial infections is well documented in natural resistance and vaccineinduced immunity against Mycobacterium Tuberculosis. However, many other populations of leukocytes contribute to innate and adaptive immunity against mycobacteria. Among these, non-conventional T cells recognizing lipid antigens presented by the CD1 antigen presentation system have attracted particular interest. In this chapter, we review the basic immunobiology and potential antimycobacterial properties of a subset of CD1-restricted T cells that have come to be known as Natural Killer T cells. This group of lipid reactive T cells is notable for its high level of conservation between humans and mice, thus enabling a wide range of highly informative studies in mouse models. As reviewed below, NKT cells appear to have subtle but potentially significant activities in the host response to mycobacteria. Importantly, they also provide a framework for investigations into other types of lipid antigen-specific T cells that may be more abundant in larger mammals such as humans.
AB - The critical role of peptide antigen-specific T cells in controlling mycobacterial infections is well documented in natural resistance and vaccineinduced immunity against Mycobacterium Tuberculosis. However, many other populations of leukocytes contribute to innate and adaptive immunity against mycobacteria. Among these, non-conventional T cells recognizing lipid antigens presented by the CD1 antigen presentation system have attracted particular interest. In this chapter, we review the basic immunobiology and potential antimycobacterial properties of a subset of CD1-restricted T cells that have come to be known as Natural Killer T cells. This group of lipid reactive T cells is notable for its high level of conservation between humans and mice, thus enabling a wide range of highly informative studies in mouse models. As reviewed below, NKT cells appear to have subtle but potentially significant activities in the host response to mycobacteria. Importantly, they also provide a framework for investigations into other types of lipid antigen-specific T cells that may be more abundant in larger mammals such as humans.
KW - Apolipoprotein E (ApoE)
KW - CD1D1 genes
KW - CD1d expression
KW - Cortical thymocytes
KW - Glycolipids
KW - Invariant NKT (iNKT) cells
KW - Macrophages
KW - Mammalian major histocompatibility complex (MHC) class I proteins
KW - Microsomal triglyceride transfer protein (MTP)
KW - Mycobacterium Tuberculosis
KW - Mycobacterium bovis BCG
KW - Natural killer T (NKT) cells
KW - Niemann-pick type C2 (NPC2) protein
KW - Saposin family (saposins AD)
KW - T cell antigen receptors
UR - http://www.scopus.com/inward/record.url?scp=84879525654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879525654&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-6111-1_11
DO - 10.1007/978-1-4614-6111-1_11
M3 - Chapter
C2 - 23468111
AN - SCOPUS:84879525654
SN - 9781461461104
T3 - Advances in Experimental Medicine and Biology
SP - 199
EP - 223
BT - The New Paradigm of Immunity to Tuberculosis
PB - Springer New York LLC
ER -
