CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool

Jean Pierre Rosat, Ethan P. Grant, Evan M. Beckman, Christopher C. Dascher, Peter A. Sieling, Daphney Frederique, Robert L. Modlin, Steven A. Porcelli, Stephen T. Furlong, Michael B. Brenner

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

It is generally accepted that TCR αβ+ CD8+ T cells recognize immunogenic peptides bound to MHC-encoded class I molecules. This recognition is a major component of the cellular response mediating immune protection and recovery from viral infections and from certain intracellular bacterial infections. Here, we report two human CD8+ TCR αβ+ T cell lines specific for Mycobacterium tuberculosis Ags presented in the context of CD1a or CD1c Ag-presenting molecules. These T cells recognize lipid Ags and display cytotoxicity as well as strong Th cell type I cytokine responses. By extending presentation by the CD1 system to the major TCR αβ CD8+ T cell pool, this system gains wider applicability beyond the double negative subset of T cells previously shown to have this reactivity. This implies that previous assumptions about the role of CD8+ T cells in microbial immunity may require revision as the relative proportions of CD1-restricted and MHC class I-restricted CD8+ T cells are further defined.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalJournal of Immunology
Volume162
Issue number1
StatePublished - Jan 1 1999
Externally publishedYes

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T-Lymphocytes
Lipids
Antigens
T-Lymphocyte Subsets
Virus Diseases
Mycobacterium tuberculosis
Bacterial Infections
Cellular Immunity
Immunity
Cytokines
Cell Line
Peptides

ASJC Scopus subject areas

  • Immunology

Cite this

Rosat, J. P., Grant, E. P., Beckman, E. M., Dascher, C. C., Sieling, P. A., Frederique, D., ... Brenner, M. B. (1999). CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool. Journal of Immunology, 162(1), 366-371.

CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool. / Rosat, Jean Pierre; Grant, Ethan P.; Beckman, Evan M.; Dascher, Christopher C.; Sieling, Peter A.; Frederique, Daphney; Modlin, Robert L.; Porcelli, Steven A.; Furlong, Stephen T.; Brenner, Michael B.

In: Journal of Immunology, Vol. 162, No. 1, 01.01.1999, p. 366-371.

Research output: Contribution to journalArticle

Rosat, JP, Grant, EP, Beckman, EM, Dascher, CC, Sieling, PA, Frederique, D, Modlin, RL, Porcelli, SA, Furlong, ST & Brenner, MB 1999, 'CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool', Journal of Immunology, vol. 162, no. 1, pp. 366-371.
Rosat JP, Grant EP, Beckman EM, Dascher CC, Sieling PA, Frederique D et al. CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool. Journal of Immunology. 1999 Jan 1;162(1):366-371.
Rosat, Jean Pierre ; Grant, Ethan P. ; Beckman, Evan M. ; Dascher, Christopher C. ; Sieling, Peter A. ; Frederique, Daphney ; Modlin, Robert L. ; Porcelli, Steven A. ; Furlong, Stephen T. ; Brenner, Michael B. / CD1-restricted microbial lipid antigen-specific recognition found in the CD8+ αβ T cell pool. In: Journal of Immunology. 1999 ; Vol. 162, No. 1. pp. 366-371.
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