CD1 - A new paradigm for antigen presentation and T cell activation

Masahiko Sugita, D. Branch Moody, Robin M. Jackman, Ethan P. Grant, Jean Pierre Rosat, Samuel M. Behar, Peter J. Peters, Steven A. Porcelli, Michael B. Brenner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Despite identification of the CD1 family of molecules in the late 1970s, the function of CD1 was undetermined for more than a decade. Recent evidence has established that CD1 molecules comprise a novel lineage of antigen- presenting molecules, distinct from major histocompatibility complex (MHC) class I and class H molecules. Unlike the MHC molecules, which bind short peptides in their antigen-binding groove for presentation to either CD4+ or CD8+ T cells bearing αβ T cell receptors, the CD1 molecules appear to accommodate lipid and glycolipid antigens in their hydrophobic cavity for presentation to a wide variety of T cells, including double-negative αβ and γδ T cells and CD8+ αβ T cells. By using a unique cytoplasmic signal, some CD1 molecules traffic to endosomal compartments for sampling mycobacteria-derived lipid antigens, and subsequently lipid antigen-loaded CD1 molecules are expressed on the cell surface to activate specific T cells. These CD1-restricted T cells kill mycobacteria-infected cells and secrete interferon-γ, indicating a potential role of CD1-mediated T cell responses in clearing mycobacterial infection. The identification of an MHC-independent antigen presentation pathway for nonpeptide antigens provides new insights into immunoregulation and host defense.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalClinical Immunology and Immunopathology
Volume87
Issue number1
DOIs
StatePublished - Apr 1998
Externally publishedYes

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Antigen Presentation
T-Lymphocytes
Antigens
Major Histocompatibility Complex
Mycobacterium
Lipids
CD1 Antigens
Glycolipids
T-Cell Antigen Receptor
Interferons
Peptides
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pathology and Forensic Medicine

Cite this

Sugita, M., Moody, D. B., Jackman, R. M., Grant, E. P., Rosat, J. P., Behar, S. M., ... Brenner, M. B. (1998). CD1 - A new paradigm for antigen presentation and T cell activation. Clinical Immunology and Immunopathology, 87(1), 8-14. https://doi.org/10.1006/clin.1997.4500

CD1 - A new paradigm for antigen presentation and T cell activation. / Sugita, Masahiko; Moody, D. Branch; Jackman, Robin M.; Grant, Ethan P.; Rosat, Jean Pierre; Behar, Samuel M.; Peters, Peter J.; Porcelli, Steven A.; Brenner, Michael B.

In: Clinical Immunology and Immunopathology, Vol. 87, No. 1, 04.1998, p. 8-14.

Research output: Contribution to journalArticle

Sugita, M, Moody, DB, Jackman, RM, Grant, EP, Rosat, JP, Behar, SM, Peters, PJ, Porcelli, SA & Brenner, MB 1998, 'CD1 - A new paradigm for antigen presentation and T cell activation', Clinical Immunology and Immunopathology, vol. 87, no. 1, pp. 8-14. https://doi.org/10.1006/clin.1997.4500
Sugita, Masahiko ; Moody, D. Branch ; Jackman, Robin M. ; Grant, Ethan P. ; Rosat, Jean Pierre ; Behar, Samuel M. ; Peters, Peter J. ; Porcelli, Steven A. ; Brenner, Michael B. / CD1 - A new paradigm for antigen presentation and T cell activation. In: Clinical Immunology and Immunopathology. 1998 ; Vol. 87, No. 1. pp. 8-14.
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