CC chemokine receptor 5 genotype and susceptibility to transmission of human immunodeficiency virus type 1 in women

Sean Philpott, Barbara Weiser, Patrick Tarwater, Sten H. Vermund, Cynthia A. Kleeberger, Stephen J. Gange, Kathryn Anastos, Mardge Cohen, Ruth M. Greenblatt, Andrea Kovacs, Howard Minkoff, Mary A. Young, Paolo Miotti, Michelle Dupuis, Chih Hsiung Chen, Harold Burger

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29 Scopus citations

Abstract

The human gene for CC chemokine receptor 5, a coreceptor for human immunodeficiency virus type 1 (HIV-1), affects susceptibility to infection. Most studies of predominantly male cohorts found that individuals carrying a homozygous deleted form of the gene, Δ32, were protected against transmission, but protection did not extend to Δ32 heterozygotes. The role played by this mutation in HIV-1 transmission to women was studied in 2605 participants in the Women's Interagency HIV Study. The Δ32 gene frequency was 0.026 for HIV-1-seropositive women and 0.040 for HIV-1-seronegative women, and statistical analyses showed that Δ32 heterozygotes were significantly less likely to be infected (odds ratio, 0.63 [95% confidence interval, 0.44-0.90]). The CCR5 Δ32 heterozygous genotype may confer partial protection against HIV-1 infection in women. Because Δ32 is rare in Africans and Asians, it seems plausible that differential genetic susceptibility, in addition to social and behavioral factors, may contribute to the rapid heterosexual spread of HIV-1 in Africa and Asia.

Original languageEnglish (US)
Pages (from-to)569-575
Number of pages7
JournalJournal of Infectious Diseases
Volume187
Issue number4
DOIs
StatePublished - Feb 15 2003

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Philpott, S., Weiser, B., Tarwater, P., Vermund, S. H., Kleeberger, C. A., Gange, S. J., Anastos, K., Cohen, M., Greenblatt, R. M., Kovacs, A., Minkoff, H., Young, M. A., Miotti, P., Dupuis, M., Chen, C. H., & Burger, H. (2003). CC chemokine receptor 5 genotype and susceptibility to transmission of human immunodeficiency virus type 1 in women. Journal of Infectious Diseases, 187(4), 569-575. https://doi.org/10.1086/367995