TY - JOUR
T1 - CC chemokine receptor 5 genotype and susceptibility to transmission of human immunodeficiency virus type 1 in women
AU - Philpott, Sean
AU - Weiser, Barbara
AU - Tarwater, Patrick
AU - Vermund, Sten H.
AU - Kleeberger, Cynthia A.
AU - Gange, Stephen J.
AU - Anastos, Kathryn
AU - Cohen, Mardge
AU - Greenblatt, Ruth M.
AU - Kovacs, Andrea
AU - Minkoff, Howard
AU - Young, Mary A.
AU - Miotti, Paolo
AU - Dupuis, Michelle
AU - Chen, Chih Hsiung
AU - Burger, Harold
N1 - Funding Information:
Financial support: National Institute of Allergy and Infectious Diseases, with supplemental funding from National Cancer Institute, National Institute of Child Health and Human Development (NICHD), National Institute of Drug Abuse, National Institute of Dental Research, Agency for Health Care Policy and Research, and Centers for Disease Control and Prevention (grants U01-AI-35004, U01-AI-31834, U01-AI-34994, U01-AI-34989, U01-HD-32632, U01-AI-34993, U01-AI-42590, and RO1-AI-42555); NICHD National Research Service Award (1F32-HD08478-01 to S.P.).
PY - 2003/2/15
Y1 - 2003/2/15
N2 - The human gene for CC chemokine receptor 5, a coreceptor for human immunodeficiency virus type 1 (HIV-1), affects susceptibility to infection. Most studies of predominantly male cohorts found that individuals carrying a homozygous deleted form of the gene, Δ32, were protected against transmission, but protection did not extend to Δ32 heterozygotes. The role played by this mutation in HIV-1 transmission to women was studied in 2605 participants in the Women's Interagency HIV Study. The Δ32 gene frequency was 0.026 for HIV-1-seropositive women and 0.040 for HIV-1-seronegative women, and statistical analyses showed that Δ32 heterozygotes were significantly less likely to be infected (odds ratio, 0.63 [95% confidence interval, 0.44-0.90]). The CCR5 Δ32 heterozygous genotype may confer partial protection against HIV-1 infection in women. Because Δ32 is rare in Africans and Asians, it seems plausible that differential genetic susceptibility, in addition to social and behavioral factors, may contribute to the rapid heterosexual spread of HIV-1 in Africa and Asia.
AB - The human gene for CC chemokine receptor 5, a coreceptor for human immunodeficiency virus type 1 (HIV-1), affects susceptibility to infection. Most studies of predominantly male cohorts found that individuals carrying a homozygous deleted form of the gene, Δ32, were protected against transmission, but protection did not extend to Δ32 heterozygotes. The role played by this mutation in HIV-1 transmission to women was studied in 2605 participants in the Women's Interagency HIV Study. The Δ32 gene frequency was 0.026 for HIV-1-seropositive women and 0.040 for HIV-1-seronegative women, and statistical analyses showed that Δ32 heterozygotes were significantly less likely to be infected (odds ratio, 0.63 [95% confidence interval, 0.44-0.90]). The CCR5 Δ32 heterozygous genotype may confer partial protection against HIV-1 infection in women. Because Δ32 is rare in Africans and Asians, it seems plausible that differential genetic susceptibility, in addition to social and behavioral factors, may contribute to the rapid heterosexual spread of HIV-1 in Africa and Asia.
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U2 - 10.1086/367995
DO - 10.1086/367995
M3 - Article
C2 - 12599073
AN - SCOPUS:0037443108
SN - 0022-1899
VL - 187
SP - 569
EP - 575
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -