Catheter related sepsis during long-term parenteral nutrition in paediatric gastroenterology patients: a study of 185 consecutive central venous catheters

O. Goulet, M. Larchet, J. L. Gaillard, V. Goulet, D. Jan, Y. Revillon, S. Lortat-Jacob, P. Descamps, C. Ricour

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We report the results of a prospective study of catheter-related sepsis (CRS) in 154 gastroenterology paediatric patients treated for medical (n = 102) or surgical (n = 52) disorders. Over 2 years, 185 central venous catheters (CVC) were placed, including 155 Broviac and 30 Jonathan Shaw CVC. CVC remained in place 13,331 days (6,539 days of cyclic parenteral nutrition), with a mean catheter life of 72 days. Forty-eight episodes of CRS occurred, most of them due to coagulase-negative staphylococci (n = 29) and Staphylococcus aureus (n = 17). CRS rate was 0.26, with an overall incidence of 1 infection per 278 days of parenteral nutrition (PN). Factors significantly associated with CRS were: age 1-5 years (p < 0.01), a medical indication for treatment (p < 0.001) and summer months of PN (p < 0.01). Interestingly, CRS occurred predominantly (65%) within the first 2 months following CVC placement and the risk of infection correlated with local haemorrhage at the time of insertion (p < 0.01). Appropriate systemic therapy, without removing the catheter, permitted resolution of 90.9% ( 40 44) of all CRS and 100% ( 28 28) of CRS due to coagulase-negative staphylococci.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalClinical Nutrition
Volume9
Issue number2
DOIs
StatePublished - Apr 1990
Externally publishedYes

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

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