Catecholaminergic neurons in the parabrachial nucleus of normal individuals and patients with idiopathic Parkinson's disease

Satoshi Goto, Asao Hirano

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The parabrachial nucleus is believed to play a role in autonomic regulation. We have used the Fontana-Masson ammoniacal silver nitrate method and a tyrosine hydroxylase-immunostaining technique to demonstrate the presence of neuromelanin-containing catecholaminergic neurons in the parabrachial nucleus of normal individuals. In addition, we also show that there is a significant reduction of these catecholaminergic neurons and presence of Lewy bodies in the parabrachial nucleus of patients with idiopathic Parkinson's disease. These findings may be related to the several autonomic disturbances that may occur in idiopathic Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalAnnals of Neurology
Volume30
Issue number2
StatePublished - Aug 1991

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Parkinson Disease
Neurons
Lewy Bodies
Silver Nitrate
Tyrosine 3-Monooxygenase
Parabrachial Nucleus
ammoniacal silver
neuromelanin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Catecholaminergic neurons in the parabrachial nucleus of normal individuals and patients with idiopathic Parkinson's disease. / Goto, Satoshi; Hirano, Asao.

In: Annals of Neurology, Vol. 30, No. 2, 08.1991, p. 192-196.

Research output: Contribution to journalArticle

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