Case series

Hyponatremia associated with moderate exercise

Julian Zelingher, Chaim Putterman, Yaron Ilan, Eldad J. Dann, Fabio Zveibil, Yigal Shvil, Eithan Galun

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Exercise-induced hyponatremia is commonly believed to be associated only with extraordinary physical efforts, or particularly strenuous exercise. Hyponatremia complicating moderate exercise has not been described previously. The authors describe the characteristics of seven patients with life-threatening hyponatremia associated with mild to moderate exercise. All patients suffered from nausea, vomiting, agitation, and confusion, appearing during or after moderate physical activity. Grand real convulsions occurred in five of the patients. In laboratory results, hyponatremia was as low as 115 mEq/L, with a relatively high sodium concentration in the urine. High serum creatine kinase activity levels were found in most of the patients. All patients were discharged in good condition, without neurologic sequela. The authors conclude that hyponatremia is a possible complication of moderate exercise, and not only of endurance sports, and that exercise-induced hyponatremia can produce severe neurologic manifestations. The mechanism of the hyponatremia is unclear, but may be due to a hemodynamically inappropriate stimulus for antidiuretic hormone secretion.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume311
Issue number2
DOIs
StatePublished - Feb 1996

Fingerprint

Hyponatremia
Exercise
Inappropriate ADH Syndrome
Physical Exertion
Creatine Kinase
Neurologic Manifestations
Nausea
Nervous System
Vomiting
Sports
Seizures
Sodium
Urine
Serum

Keywords

  • Exercise
  • Hyponatremia
  • Inappropriate antidiuretic hormone secretion
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Case series : Hyponatremia associated with moderate exercise. / Zelingher, Julian; Putterman, Chaim; Ilan, Yaron; Dann, Eldad J.; Zveibil, Fabio; Shvil, Yigal; Galun, Eithan.

In: American Journal of the Medical Sciences, Vol. 311, No. 2, 02.1996, p. 86-91.

Research output: Contribution to journalArticle

Zelingher, Julian ; Putterman, Chaim ; Ilan, Yaron ; Dann, Eldad J. ; Zveibil, Fabio ; Shvil, Yigal ; Galun, Eithan. / Case series : Hyponatremia associated with moderate exercise. In: American Journal of the Medical Sciences. 1996 ; Vol. 311, No. 2. pp. 86-91.
@article{54fa0de44870447f81b45f1740dc5ed0,
title = "Case series: Hyponatremia associated with moderate exercise",
abstract = "Exercise-induced hyponatremia is commonly believed to be associated only with extraordinary physical efforts, or particularly strenuous exercise. Hyponatremia complicating moderate exercise has not been described previously. The authors describe the characteristics of seven patients with life-threatening hyponatremia associated with mild to moderate exercise. All patients suffered from nausea, vomiting, agitation, and confusion, appearing during or after moderate physical activity. Grand real convulsions occurred in five of the patients. In laboratory results, hyponatremia was as low as 115 mEq/L, with a relatively high sodium concentration in the urine. High serum creatine kinase activity levels were found in most of the patients. All patients were discharged in good condition, without neurologic sequela. The authors conclude that hyponatremia is a possible complication of moderate exercise, and not only of endurance sports, and that exercise-induced hyponatremia can produce severe neurologic manifestations. The mechanism of the hyponatremia is unclear, but may be due to a hemodynamically inappropriate stimulus for antidiuretic hormone secretion.",
keywords = "Exercise, Hyponatremia, Inappropriate antidiuretic hormone secretion, Rhabdomyolysis",
author = "Julian Zelingher and Chaim Putterman and Yaron Ilan and Dann, {Eldad J.} and Fabio Zveibil and Yigal Shvil and Eithan Galun",
year = "1996",
month = "2",
doi = "10.1097/00000441-199602000-00007",
language = "English (US)",
volume = "311",
pages = "86--91",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Case series

T2 - Hyponatremia associated with moderate exercise

AU - Zelingher, Julian

AU - Putterman, Chaim

AU - Ilan, Yaron

AU - Dann, Eldad J.

AU - Zveibil, Fabio

AU - Shvil, Yigal

AU - Galun, Eithan

PY - 1996/2

Y1 - 1996/2

N2 - Exercise-induced hyponatremia is commonly believed to be associated only with extraordinary physical efforts, or particularly strenuous exercise. Hyponatremia complicating moderate exercise has not been described previously. The authors describe the characteristics of seven patients with life-threatening hyponatremia associated with mild to moderate exercise. All patients suffered from nausea, vomiting, agitation, and confusion, appearing during or after moderate physical activity. Grand real convulsions occurred in five of the patients. In laboratory results, hyponatremia was as low as 115 mEq/L, with a relatively high sodium concentration in the urine. High serum creatine kinase activity levels were found in most of the patients. All patients were discharged in good condition, without neurologic sequela. The authors conclude that hyponatremia is a possible complication of moderate exercise, and not only of endurance sports, and that exercise-induced hyponatremia can produce severe neurologic manifestations. The mechanism of the hyponatremia is unclear, but may be due to a hemodynamically inappropriate stimulus for antidiuretic hormone secretion.

AB - Exercise-induced hyponatremia is commonly believed to be associated only with extraordinary physical efforts, or particularly strenuous exercise. Hyponatremia complicating moderate exercise has not been described previously. The authors describe the characteristics of seven patients with life-threatening hyponatremia associated with mild to moderate exercise. All patients suffered from nausea, vomiting, agitation, and confusion, appearing during or after moderate physical activity. Grand real convulsions occurred in five of the patients. In laboratory results, hyponatremia was as low as 115 mEq/L, with a relatively high sodium concentration in the urine. High serum creatine kinase activity levels were found in most of the patients. All patients were discharged in good condition, without neurologic sequela. The authors conclude that hyponatremia is a possible complication of moderate exercise, and not only of endurance sports, and that exercise-induced hyponatremia can produce severe neurologic manifestations. The mechanism of the hyponatremia is unclear, but may be due to a hemodynamically inappropriate stimulus for antidiuretic hormone secretion.

KW - Exercise

KW - Hyponatremia

KW - Inappropriate antidiuretic hormone secretion

KW - Rhabdomyolysis

UR - http://www.scopus.com/inward/record.url?scp=0030062722&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030062722&partnerID=8YFLogxK

U2 - 10.1097/00000441-199602000-00007

DO - 10.1097/00000441-199602000-00007

M3 - Article

VL - 311

SP - 86

EP - 91

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 2

ER -