Case report: Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis

Fouad N. Boctor, Edward Gorak, Jeffrey W. Prichard, Masoud Firouzi, William Difilippo

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Warm autoimmune hemolytic anemia (WAIHA), a rare disease (0.2-1 per 100,000 population), ranges from an indolent form with mild hemolysis to a life-threatening condition that necessitates transfusion of incompatible red cells. WAIHA can be either idiopathic or secondary to medications or to a lymphoproliferative disorder. We report a case of profound hemolytic anemia in a liver-transplant eligible patient who was diagnosed with cirrhosis secondary to non-alcoholic steatohepatitis (NASH). The patient initially was treated with red cell transfusion, iv immunoglobulin, and steroids. He developed acute renal failure that required dialysis. Subsequent management included plasmapheresis and rituximab therapy. The patient developed hepato-renal syndrome and died from progressive hepatic failure. To our knowledge, this is the first report of an association between NASH and WAIHA.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalAnnals of Clinical and Laboratory Science
Volume38
Issue number3
Publication statusPublished - Jun 1 2008

    Fingerprint

Keywords

  • Autoimmune hemolytic anemia
  • Hepatic cirrhosis
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

Cite this

Boctor, F. N., Gorak, E., Prichard, J. W., Firouzi, M., & Difilippo, W. (2008). Case report: Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis. Annals of Clinical and Laboratory Science, 38(3), 273-276.