Case report

Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis

Fouad N. Boctor, Edward Gorak, Jeffrey W. Prichard, Masoud Firouzi, William Difilippo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Warm autoimmune hemolytic anemia (WAIHA), a rare disease (0.2-1 per 100,000 population), ranges from an indolent form with mild hemolysis to a life-threatening condition that necessitates transfusion of incompatible red cells. WAIHA can be either idiopathic or secondary to medications or to a lymphoproliferative disorder. We report a case of profound hemolytic anemia in a liver-transplant eligible patient who was diagnosed with cirrhosis secondary to non-alcoholic steatohepatitis (NASH). The patient initially was treated with red cell transfusion, iv immunoglobulin, and steroids. He developed acute renal failure that required dialysis. Subsequent management included plasmapheresis and rituximab therapy. The patient developed hepato-renal syndrome and died from progressive hepatic failure. To our knowledge, this is the first report of an association between NASH and WAIHA.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalAnnals of Clinical and Laboratory Science
Volume38
Issue number3
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

Autoimmune Hemolytic Anemia
Fatty Liver
Cells
Transplants
Dialysis
Liver
Immunoglobulins
Plasmapheresis
Lymphoproliferative Disorders
Hemolytic Anemia
Steroids
Liver Failure
Rare Diseases
Hemolysis
Acute Kidney Injury
Fibrosis
Kidney
Population
Therapeutics
Rituximab

Keywords

  • Autoimmune hemolytic anemia
  • Hepatic cirrhosis
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry
  • Molecular Biology
  • Immunology
  • Microbiology
  • Hematology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Boctor, F. N., Gorak, E., Prichard, J. W., Firouzi, M., & Difilippo, W. (2008). Case report: Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis. Annals of Clinical and Laboratory Science, 38(3), 273-276.

Case report : Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis. / Boctor, Fouad N.; Gorak, Edward; Prichard, Jeffrey W.; Firouzi, Masoud; Difilippo, William.

In: Annals of Clinical and Laboratory Science, Vol. 38, No. 3, 06.2008, p. 273-276.

Research output: Contribution to journalArticle

Boctor, FN, Gorak, E, Prichard, JW, Firouzi, M & Difilippo, W 2008, 'Case report: Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis', Annals of Clinical and Laboratory Science, vol. 38, no. 3, pp. 273-276.
Boctor, Fouad N. ; Gorak, Edward ; Prichard, Jeffrey W. ; Firouzi, Masoud ; Difilippo, William. / Case report : Unusual warm autoimmune hemolytic anemia in non-alcoholic steatohepatitis. In: Annals of Clinical and Laboratory Science. 2008 ; Vol. 38, No. 3. pp. 273-276.
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