Carrying yourself: Self antigen composition of the lymphatic fluid

Laura Santambrogio; Lawrence J. Stern

doi:10.1089/lrb.2013.0009

Carrying yourself: Self antigen composition of the lymphatic fluid

Laura Santambrogio, Lawrence J. Stern

Pathology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Advances in proteomics methodology and instrumentation have allowed detailed characterization of the composition of lymph. Far from being a simple ultrafiltrate of blood plasma, lymph has been shown to carry a rich repertoire of proteins and peptides reflecting the tissue of origin and its physiological state. Peptides derived from lymph can be loaded on the MHCII proteins, particularly those present on immature and/or inactivated antigen presenting cells, and may play an important role in maintenance of peripheral tolerance.

Original language	English (US)
Pages (from-to)	149-154
Number of pages	6
Journal	Lymphatic research and biology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1089/lrb.2013.0009
State	Published - Sep 1 2013

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Carrying yourself: Self antigen composition of the lymphatic fluid

Abstract

ASJC Scopus subject areas

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