Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients

Philip W. Lebowitz; M. Elizabeth Cote; Alfred L. Daniels; J. A.Jeevendra Martyn; Richard S. Teplick; J. Kenneth Davison; N. Sunder

doi:10.1007/BF03007711

Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients

Philip W. Lebowitz, M. Elizabeth Cote, Alfred L. Daniels, J. A.Jeevendra Martyn, Richard S. Teplick, J. Kenneth Davison, N. Sunder

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The cardiovascular effects of midazolam (0.15 mg kg-) and thiopentone (3.0 mg kg₁) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class HI patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemoaynamic point of view.

Original language	English (US)
Pages (from-to)	19-23
Number of pages	5
Journal	Canadian Anaesthetists' Society Journal
Volume	30
Issue number	1
DOIs	https://doi.org/10.1007/BF03007711
State	Published - Jan 1983
Externally published	Yes

Keywords

Anaesthetics
Intravenous: midazolam
blood pressure: drug effects
drug effects
heart: cardiac output
thiopentone

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1007/BF03007711

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title = "Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients",

abstract = "The cardiovascular effects of midazolam (0.15 mg kg-) and thiopentone (3.0 mg kg1) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class HI patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemoaynamic point of view.",

keywords = "Anaesthetics, Intravenous: midazolam, blood pressure: drug effects, drug effects, heart: cardiac output, thiopentone",

author = "Lebowitz, {Philip W.} and Cote, {M. Elizabeth} and Daniels, {Alfred L.} and Martyn, {J. A.Jeevendra} and Teplick, {Richard S.} and Davison, {J. Kenneth} and N. Sunder",

year = "1983",

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AU - Lebowitz, Philip W.

AU - Cote, M. Elizabeth

AU - Daniels, Alfred L.

AU - Martyn, J. A.Jeevendra

AU - Teplick, Richard S.

AU - Davison, J. Kenneth

AU - Sunder, N.

PY - 1983/1

Y1 - 1983/1

N2 - The cardiovascular effects of midazolam (0.15 mg kg-) and thiopentone (3.0 mg kg1) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class HI patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemoaynamic point of view.

AB - The cardiovascular effects of midazolam (0.15 mg kg-) and thiopentone (3.0 mg kg1) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class HI patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemoaynamic point of view.

KW - Anaesthetics

KW - Intravenous: midazolam

KW - blood pressure: drug effects

KW - drug effects

KW - heart: cardiac output

KW - thiopentone

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Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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