Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients

Philip W. Lebowitz, M. Elizabeth Cote, Alfred L. Daniels, J. A.Jeevendra Martyn, Richard S. Teplick, J. Kenneth Davison, N. Sunder

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18 Scopus citations

Abstract

The cardiovascular effects of midazolam (0.15 mg kg-) and thiopentone (3.0 mg kg1) were compared during induction of anaesthesia in 20 American Society of Anesthesiologists class HI patients. In patients given thiopentone (N = 11), cardiac output, mean arterial pressure, heart rate, and systemic vascular resistance all decreased significantly over the course of the study period; mean right atrial pressure rose slightly, and stroke volume remained the same. Patients receiving midazolam (N = 9) experienced similar haemodynamic changes which were significant relative to baseline only for the fall in mean arterial pressure and the rise in mean right atrial pressure at ten minutes. There were no significant differences between the two groups. Midazolam thus appears to be at least as acceptable an induction agent as thiopentone in ill patients, from a haemoaynamic point of view.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalCanadian Anaesthetists' Society Journal
Volume30
Issue number1
DOIs
StatePublished - Jan 1 1983

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Keywords

  • Anaesthetics
  • Intravenous: midazolam
  • blood pressure: drug effects
  • drug effects
  • heart: cardiac output
  • thiopentone

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Lebowitz, P. W., Cote, M. E., Daniels, A. L., Martyn, J. A. J., Teplick, R. S., Davison, J. K., & Sunder, N. (1983). Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in Ill surgical patients. Canadian Anaesthetists' Society Journal, 30(1), 19-23. https://doi.org/10.1007/BF03007711