Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters

Michael D. Weiden, Bushra Naveed, Sophia Kwon, Soo Jung Cho, Ashley L. Comfort, David J. Prezant, William N. Rom, Anna Nolan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Pulmonary vascular loss is an early feature of chronic obstructive pulmonary disease. Biomarkers of inflammation and of metabolic syndrome predict loss of lung function in World Trade Center (WTC) lung injury (LI). We investigated if other cardiovascular disease (CVD) biomarkers also predicted WTC-LI. This nested case-cohort study used 801 never-smoker, WTC-exposed firefighters with normal pre-9/11 lung function presenting for subspecialty pulmonary evaluation (SPE) before March 2008. A representative subcohort of 124 out of 801 subjects with serum drawn within 6 months of 9/11 defined CVD biomarker distribution. Post-9/11 forced expiratory volume in 1 s (FEV 1) at defined cases were as follows: susceptible WTC-LI cases with FEV1 ≤77% predicted (66 out of 801) and resistant WTC-LI cases with FEV1 ≥107% predicted (68 out of 801). All models were adjusted for WTC exposure intensity, body mass index at SPE, age on 9/11 and pre-9/11 FEV1. Susceptible WTC-LI cases had higher levels of apolipoprotein-AII, C-reactive protein and macrophage inflammatory protein-4 with significant relative risks (RRs) of 3.85, 3.93 and 0.26, respectively, with an area under the curve (AUC) of 0.858. Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). Biomarkers of CVD in serum 6 months post-9/11 predicted either susceptibility or resistance to WTC-LI. These biomarkers may define pathways either producing or protecting subjects from pulmonary vascular disease and associated loss of lung function after an irritant exposure. Copyright

Original languageEnglish (US)
Pages (from-to)1023-1030
Number of pages8
JournalEuropean Respiratory Journal
Volume41
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Firefighters
Lung Injury
Dust
Biomarkers
Lung
Cardiovascular Diseases
Area Under Curve
Apolipoproteins C
Apolipoprotein A-II
Macrophage Inflammatory Proteins
Vascular Cell Adhesion Molecule-1
Irritants
Forced Expiratory Volume
Serum
Vascular Diseases
C-Reactive Protein
Chronic Obstructive Pulmonary Disease
Peroxidase
Lung Diseases
Blood Vessels

Keywords

  • Airway inflammation
  • Cytokines
  • Pulmonary function testing

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters. / Weiden, Michael D.; Naveed, Bushra; Kwon, Sophia; Cho, Soo Jung; Comfort, Ashley L.; Prezant, David J.; Rom, William N.; Nolan, Anna.

In: European Respiratory Journal, Vol. 41, No. 5, 01.05.2013, p. 1023-1030.

Research output: Contribution to journalArticle

Weiden, Michael D. ; Naveed, Bushra ; Kwon, Sophia ; Cho, Soo Jung ; Comfort, Ashley L. ; Prezant, David J. ; Rom, William N. ; Nolan, Anna. / Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters. In: European Respiratory Journal. 2013 ; Vol. 41, No. 5. pp. 1023-1030.
@article{a700a939ef584566848e1b81beb274d6,
title = "Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters",
abstract = "Pulmonary vascular loss is an early feature of chronic obstructive pulmonary disease. Biomarkers of inflammation and of metabolic syndrome predict loss of lung function in World Trade Center (WTC) lung injury (LI). We investigated if other cardiovascular disease (CVD) biomarkers also predicted WTC-LI. This nested case-cohort study used 801 never-smoker, WTC-exposed firefighters with normal pre-9/11 lung function presenting for subspecialty pulmonary evaluation (SPE) before March 2008. A representative subcohort of 124 out of 801 subjects with serum drawn within 6 months of 9/11 defined CVD biomarker distribution. Post-9/11 forced expiratory volume in 1 s (FEV 1) at defined cases were as follows: susceptible WTC-LI cases with FEV1 ≤77{\%} predicted (66 out of 801) and resistant WTC-LI cases with FEV1 ≥107{\%} predicted (68 out of 801). All models were adjusted for WTC exposure intensity, body mass index at SPE, age on 9/11 and pre-9/11 FEV1. Susceptible WTC-LI cases had higher levels of apolipoprotein-AII, C-reactive protein and macrophage inflammatory protein-4 with significant relative risks (RRs) of 3.85, 3.93 and 0.26, respectively, with an area under the curve (AUC) of 0.858. Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). Biomarkers of CVD in serum 6 months post-9/11 predicted either susceptibility or resistance to WTC-LI. These biomarkers may define pathways either producing or protecting subjects from pulmonary vascular disease and associated loss of lung function after an irritant exposure. Copyright",
keywords = "Airway inflammation, Cytokines, Pulmonary function testing",
author = "Weiden, {Michael D.} and Bushra Naveed and Sophia Kwon and Cho, {Soo Jung} and Comfort, {Ashley L.} and Prezant, {David J.} and Rom, {William N.} and Anna Nolan",
year = "2013",
month = "5",
day = "1",
doi = "10.1183/09031936.00077012",
language = "English (US)",
volume = "41",
pages = "1023--1030",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "5",

}

TY - JOUR

T1 - Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters

AU - Weiden, Michael D.

AU - Naveed, Bushra

AU - Kwon, Sophia

AU - Cho, Soo Jung

AU - Comfort, Ashley L.

AU - Prezant, David J.

AU - Rom, William N.

AU - Nolan, Anna

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Pulmonary vascular loss is an early feature of chronic obstructive pulmonary disease. Biomarkers of inflammation and of metabolic syndrome predict loss of lung function in World Trade Center (WTC) lung injury (LI). We investigated if other cardiovascular disease (CVD) biomarkers also predicted WTC-LI. This nested case-cohort study used 801 never-smoker, WTC-exposed firefighters with normal pre-9/11 lung function presenting for subspecialty pulmonary evaluation (SPE) before March 2008. A representative subcohort of 124 out of 801 subjects with serum drawn within 6 months of 9/11 defined CVD biomarker distribution. Post-9/11 forced expiratory volume in 1 s (FEV 1) at defined cases were as follows: susceptible WTC-LI cases with FEV1 ≤77% predicted (66 out of 801) and resistant WTC-LI cases with FEV1 ≥107% predicted (68 out of 801). All models were adjusted for WTC exposure intensity, body mass index at SPE, age on 9/11 and pre-9/11 FEV1. Susceptible WTC-LI cases had higher levels of apolipoprotein-AII, C-reactive protein and macrophage inflammatory protein-4 with significant relative risks (RRs) of 3.85, 3.93 and 0.26, respectively, with an area under the curve (AUC) of 0.858. Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). Biomarkers of CVD in serum 6 months post-9/11 predicted either susceptibility or resistance to WTC-LI. These biomarkers may define pathways either producing or protecting subjects from pulmonary vascular disease and associated loss of lung function after an irritant exposure. Copyright

AB - Pulmonary vascular loss is an early feature of chronic obstructive pulmonary disease. Biomarkers of inflammation and of metabolic syndrome predict loss of lung function in World Trade Center (WTC) lung injury (LI). We investigated if other cardiovascular disease (CVD) biomarkers also predicted WTC-LI. This nested case-cohort study used 801 never-smoker, WTC-exposed firefighters with normal pre-9/11 lung function presenting for subspecialty pulmonary evaluation (SPE) before March 2008. A representative subcohort of 124 out of 801 subjects with serum drawn within 6 months of 9/11 defined CVD biomarker distribution. Post-9/11 forced expiratory volume in 1 s (FEV 1) at defined cases were as follows: susceptible WTC-LI cases with FEV1 ≤77% predicted (66 out of 801) and resistant WTC-LI cases with FEV1 ≥107% predicted (68 out of 801). All models were adjusted for WTC exposure intensity, body mass index at SPE, age on 9/11 and pre-9/11 FEV1. Susceptible WTC-LI cases had higher levels of apolipoprotein-AII, C-reactive protein and macrophage inflammatory protein-4 with significant relative risks (RRs) of 3.85, 3.93 and 0.26, respectively, with an area under the curve (AUC) of 0.858. Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). Biomarkers of CVD in serum 6 months post-9/11 predicted either susceptibility or resistance to WTC-LI. These biomarkers may define pathways either producing or protecting subjects from pulmonary vascular disease and associated loss of lung function after an irritant exposure. Copyright

KW - Airway inflammation

KW - Cytokines

KW - Pulmonary function testing

UR - http://www.scopus.com/inward/record.url?scp=84877099418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877099418&partnerID=8YFLogxK

U2 - 10.1183/09031936.00077012

DO - 10.1183/09031936.00077012

M3 - Article

VL - 41

SP - 1023

EP - 1030

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 5

ER -