Cardiomyogenesis in the aging and failing human heart

Jan Kajstura, Marcello Rota, Donato Cappetta, Barbara Ogórek, Christian Arranto, Yingnan Bai, João Ferreira-Martins, Sergio Signore, Fumihiro Sanada, Alex Matsuda, James Kostyla, Maria Virginia Caballero, Claudia Fiorini, David A. Dalessandro, Robert E. Michler, Federica Del Monte, Toru Hosoda, Mark A. Perrella, Annarosa Leri, Bruce A. Buchholz & 2 others Joseph Loscalzo, Piero Anversa

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Background-Two opposite views of cardiac growth are currently held; one views the heart as a static organ characterized by a large number of cardiomyocytes that are present at birth and live as long as the organism, and the other views the heart a highly plastic organ in which the myocyte compartment is restored several times during the course of life. Methods and Results-The average age of cardiomyocytes, vascular endothelial cells (ECs), and fibroblasts and their turnover rates were measured by retrospective C birth dating of cells in 19 normal hearts 2 to 78 years of age and in 17 explanted failing hearts 22 to 70 years of age. We report that the human heart is characterized by a significant turnover of ventricular myocytes, ECs, and fibroblasts, physiologically and pathologically. Myocyte, EC, and fibroblast renewal is very high shortly after birth, decreases during postnatal maturation, remains relatively constant in the adult organ, and increases dramatically with age. From 20 to 78 years of age, the adult human heart entirely replaces its myocyte, EC, and fibroblast compartment 8, 6, and 8 times, respectively. Myocyte, EC, and fibroblast regeneration is further enhanced with chronic heart failure. Conclusions-The human heart is a highly dynamic organ that retains a remarkable degree of plasticity throughout life and in the presence of chronic heart failure. However, the ability to regenerate cardiomyocytes, vascular ECs, and fibroblasts cannot prevent the manifestations of myocardial aging or oppose the negative effects of ischemic and idiopathic dilated cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)1869-1881
Number of pages13
JournalCirculation
Volume126
Issue number15
DOIs
StatePublished - Oct 9 2012

Fingerprint

Endothelial Cells
Muscle Cells
Fibroblasts
Cardiac Myocytes
Heart Failure
Parturition
Dilated Cardiomyopathy
Live Birth
Plastics
Regeneration
Growth

Keywords

  • carbon radioisotopes
  • cell proliferation
  • cytokinesis
  • myocytes, cardiac
  • radiometric dating

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Kajstura, J., Rota, M., Cappetta, D., Ogórek, B., Arranto, C., Bai, Y., ... Anversa, P. (2012). Cardiomyogenesis in the aging and failing human heart. Circulation, 126(15), 1869-1881. https://doi.org/10.1161/CIRCULATIONAHA.112.118380

Cardiomyogenesis in the aging and failing human heart. / Kajstura, Jan; Rota, Marcello; Cappetta, Donato; Ogórek, Barbara; Arranto, Christian; Bai, Yingnan; Ferreira-Martins, João; Signore, Sergio; Sanada, Fumihiro; Matsuda, Alex; Kostyla, James; Caballero, Maria Virginia; Fiorini, Claudia; Dalessandro, David A.; Michler, Robert E.; Del Monte, Federica; Hosoda, Toru; Perrella, Mark A.; Leri, Annarosa; Buchholz, Bruce A.; Loscalzo, Joseph; Anversa, Piero.

In: Circulation, Vol. 126, No. 15, 09.10.2012, p. 1869-1881.

Research output: Contribution to journalArticle

Kajstura, J, Rota, M, Cappetta, D, Ogórek, B, Arranto, C, Bai, Y, Ferreira-Martins, J, Signore, S, Sanada, F, Matsuda, A, Kostyla, J, Caballero, MV, Fiorini, C, Dalessandro, DA, Michler, RE, Del Monte, F, Hosoda, T, Perrella, MA, Leri, A, Buchholz, BA, Loscalzo, J & Anversa, P 2012, 'Cardiomyogenesis in the aging and failing human heart', Circulation, vol. 126, no. 15, pp. 1869-1881. https://doi.org/10.1161/CIRCULATIONAHA.112.118380
Kajstura J, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y et al. Cardiomyogenesis in the aging and failing human heart. Circulation. 2012 Oct 9;126(15):1869-1881. https://doi.org/10.1161/CIRCULATIONAHA.112.118380
Kajstura, Jan ; Rota, Marcello ; Cappetta, Donato ; Ogórek, Barbara ; Arranto, Christian ; Bai, Yingnan ; Ferreira-Martins, João ; Signore, Sergio ; Sanada, Fumihiro ; Matsuda, Alex ; Kostyla, James ; Caballero, Maria Virginia ; Fiorini, Claudia ; Dalessandro, David A. ; Michler, Robert E. ; Del Monte, Federica ; Hosoda, Toru ; Perrella, Mark A. ; Leri, Annarosa ; Buchholz, Bruce A. ; Loscalzo, Joseph ; Anversa, Piero. / Cardiomyogenesis in the aging and failing human heart. In: Circulation. 2012 ; Vol. 126, No. 15. pp. 1869-1881.
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AU - Kostyla, James

AU - Caballero, Maria Virginia

AU - Fiorini, Claudia

AU - Dalessandro, David A.

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AU - Hosoda, Toru

AU - Perrella, Mark A.

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