Cardiomiopatia Takotsubo: Evidenze dagli studi osservazionali e basi fisiopatologiche

Francesco Santoro, Natale Daniele Brunetti, Nicola Tarantino, Riccardo Ieva, Matteo Di Biase, Luigi Di Biase

Research output: Contribution to journalReview article

1 Scopus citations


Takotsubo cardiomyopathy is an acute reversible form of cardiac failure, firstly described in 1991, with a prognosis not favorable as previously thought. Although high levels of catecholamines have been suggested as the leading mechanism for the onset, the pathophysiology remains unclear. However, several pathophysiological explanations have been proposed, all not mutually exclusive. A complex chain of events is present, including the activation of the hypothalamic-pituitary-Adrenal axis, the surge in circulating catecholamines and subsequent cardiovascular responses. This review addresses the diagnostic classification, short and mid-Term prognosis, precipitating factors, classification into primary and secondary forms, and possible drug therapies for stress cardiomyopathy. Clinical and experimental studies are needed to further improve diagnosis and targeted therapies.

Original languageItalian
Pages (from-to)806-815
Number of pages10
JournalGiornale Italiano di Cardiologia
Issue number10
StatePublished - Oct 1 2016


  • Apical ballooning
  • Broken heart syndrome
  • Epidemiology
  • Pathophysiology
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Santoro, F., Brunetti, N. D., Tarantino, N., Ieva, R., Di Biase, M., & Di Biase, L. (2016). Cardiomiopatia Takotsubo: Evidenze dagli studi osservazionali e basi fisiopatologiche. Giornale Italiano di Cardiologia, 17(10), 806-815.