Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy

S. L. D'Ascia, C. D'Ascia, V. Marino, Angela Lombardi, R. Santulli, M. Chiariello, G. Santulli

Research output: Contribution to journalArticle

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Abstract

Aim: The aim of this study was to determine whether or not cardiac resynchronization therapy (CRT) has a favourable effect on the incidence of new-onset atrial fibrillation (AF) in a homogeneous population of patients with non-ischaemic idiopathic-dilated cardiomyopathy and severe heart failure. Methods: We designed a single-centre prospective study and enrolled 58 patients AF naïve when received CRT. After 1 year of follow-up our population was subdivided into responders (72.4%) and non-responders (27.6%), so as to compare the incidence of AF after 1, 2 and 3 years of follow-up in these two groups. Results: Already after 1 year, there was a significant (p < 0.05) difference in new-onset AF in non-responder patients with respect to responders (18.2% vs. 3.3%). These data were confirmed at 2 years (33.3% vs. 12.2%) and 3 years (50.0% vs. 15.0%) follow-up. In particular, 3 years after device implantation non-responders had an increased risk to develop new-onset AF (OR = 5.67). Conclusions: This is the first study analysing long-term effects of CRT in a homogeneous population of patients with non-ischaemic dilated cardiomyopathy, indicating the favourable role of this non-pharmacological therapy on the prevention of AF.

Original languageEnglish (US)
Pages (from-to)1149-1155
Number of pages7
JournalInternational Journal of Clinical Practice
Volume65
Issue number11
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

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Cardiac Resynchronization Therapy
Dilated Cardiomyopathy
Atrial Fibrillation
Population
Incidence
Heart Failure
Prospective Studies
Equipment and Supplies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy. / D'Ascia, S. L.; D'Ascia, C.; Marino, V.; Lombardi, Angela; Santulli, R.; Chiariello, M.; Santulli, G.

In: International Journal of Clinical Practice, Vol. 65, No. 11, 01.11.2011, p. 1149-1155.

Research output: Contribution to journalArticle

D'Ascia, S. L. ; D'Ascia, C. ; Marino, V. ; Lombardi, Angela ; Santulli, R. ; Chiariello, M. ; Santulli, G. / Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy. In: International Journal of Clinical Practice. 2011 ; Vol. 65, No. 11. pp. 1149-1155.
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