Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

Fahimeh Varzideh, Urna Kansakar, Kwame Donkor, Scott Wilson, Stanislovas S. Jankauskas, Pasquale Mone, Xujun Wang, Angela Lombardi, Gaetano Santulli

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.

Original languageEnglish (US)
Article number863238
JournalFrontiers in Cardiovascular Medicine
Volume9
DOIs
StatePublished - Apr 13 2022

Keywords

  • cardiac remodeling
  • clinical trials
  • drug development
  • epigenetics
  • heart failure
  • ischemic heart disease
  • non-coding RNA
  • oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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