Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

Fahimeh Varzideh; Urna Kansakar; Kwame Donkor; Scott Wilson; Stanislovas S. Jankauskas; Pasquale Mone; Xujun Wang; Angela Lombardi; Gaetano Santulli

doi:10.3389/fcvm.2022.863238

Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

Fahimeh Varzideh, Urna Kansakar, Kwame Donkor, Scott Wilson, Stanislovas S. Jankauskas, Pasquale Mone, Xujun Wang, Angela Lombardi, Gaetano Santulli

Medicine

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.

Original language	English (US)
Article number	863238
Journal	Frontiers in Cardiovascular Medicine
Volume	9
DOIs	https://doi.org/10.3389/fcvm.2022.863238
State	Published - Apr 13 2022

Keywords

cardiac remodeling
clinical trials
drug development
epigenetics
heart failure
ischemic heart disease
non-coding RNA
oxidative stress

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.3389/fcvm.2022.863238

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title = "Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis",

abstract = "After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.",

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T2 - Functional Contribution of microRNAs to Inflammation and Fibrosis

AU - Varzideh, Fahimeh

AU - Kansakar, Urna

AU - Donkor, Kwame

AU - Wilson, Scott

AU - Jankauskas, Stanislovas S.

AU - Mone, Pasquale

AU - Wang, Xujun

AU - Lombardi, Angela

AU - Santulli, Gaetano

PY - 2022/4/13

Y1 - 2022/4/13

N2 - After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.

AB - After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.

KW - cardiac remodeling

KW - clinical trials

KW - drug development

KW - epigenetics

KW - heart failure

KW - ischemic heart disease

KW - non-coding RNA

KW - oxidative stress

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Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

Abstract

Keywords

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