Capturing and deciphering the molecular signatures of head and neck cancer

Thomas J. Belbin, Roberto A. Lleras, Richard V. Smith, Nicolas F. Schlecht, Jihyeon Lim, Thomas M. Harris, Geoffrey Childs, Michael B. Prystowsky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Head and neck cancer, while relatively uncommon in the United States remains a prevalent condition throughout the world and potentially has substantial quality of life issues for these patients. As a disease classification, head and neck cancer, represents a diverse population of cancers which are linked anatomically, extending from the clavicles to the skull base. There are many histologic types of cancer within this grouping, although the vast majority are squamous cell carcinomas. The most significant disease sites are the oral cavity, oropharynx, larynx and hypopharynx, while other sites, such as the sinuses, are much less common and more heterogeneous. Treatment for head and neck cancer consists of surgery, radiation therapy and chemotherapy, alone or in combination. The decision to use a particular therapeutic regimen has been related to TNM stage, primary site, and comorbidity of the patient. More recently, molecular studies of head and neck cancer, such as global gene expression, methylation status, microRNA and proteomic changes, continue to identify important alterations in the genetic and molecular make-up of these tumors, all of which will be expanded upon in this chapter.

Original languageEnglish (US)
Title of host publicationCancer Genomics
Subtitle of host publicationMolecular Classification, Prognosis and Response Prediction
PublisherSpringer Netherlands
Pages97-130
Number of pages34
Volume9789400758421
ISBN (Electronic)9789400758421
ISBN (Print)9400758413, 9789400758414
DOIs
StatePublished - Sep 1 2013

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Belbin, T. J., Lleras, R. A., Smith, R. V., Schlecht, N. F., Lim, J., Harris, T. M., Childs, G., & Prystowsky, M. B. (2013). Capturing and deciphering the molecular signatures of head and neck cancer. In Cancer Genomics: Molecular Classification, Prognosis and Response Prediction (Vol. 9789400758421, pp. 97-130). Springer Netherlands. https://doi.org/10.1007/978-94-007-5842-1_4