Cancer risk assessment using genetic panel testing: Considerations for clinical application

Susan Hiraki, Erica S. Rinella, Freya Schnabel, Ruth Oratz, Harry Ostrer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines.

Original languageEnglish (US)
Pages (from-to)604-617
Number of pages14
JournalJournal of Genetic Counseling
Volume23
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Genetic Testing
Genes
Human Genome Project
Neoplasms
Genetic Counseling
Ovarian Neoplasms
Colonic Neoplasms
Guidelines
Breast Neoplasms
Technology

Keywords

  • Breast cancer
  • Cancer panels
  • Colon cancer
  • Ovarian cancer
  • Risk assessment

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Cancer risk assessment using genetic panel testing : Considerations for clinical application. / Hiraki, Susan; Rinella, Erica S.; Schnabel, Freya; Oratz, Ruth; Ostrer, Harry.

In: Journal of Genetic Counseling, Vol. 23, No. 4, 2014, p. 604-617.

Research output: Contribution to journalArticle

Hiraki, Susan ; Rinella, Erica S. ; Schnabel, Freya ; Oratz, Ruth ; Ostrer, Harry. / Cancer risk assessment using genetic panel testing : Considerations for clinical application. In: Journal of Genetic Counseling. 2014 ; Vol. 23, No. 4. pp. 604-617.
@article{320005a4714e4eabb3d13ac2424ee792,
title = "Cancer risk assessment using genetic panel testing: Considerations for clinical application",
abstract = "With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines.",
keywords = "Breast cancer, Cancer panels, Colon cancer, Ovarian cancer, Risk assessment",
author = "Susan Hiraki and Rinella, {Erica S.} and Freya Schnabel and Ruth Oratz and Harry Ostrer",
year = "2014",
doi = "10.1007/s10897-014-9695-6",
language = "English (US)",
volume = "23",
pages = "604--617",
journal = "Journal of Genetic Counseling",
issn = "1059-7700",
publisher = "Kluwer Academic/Human Sciences Press Inc.",
number = "4",

}

TY - JOUR

T1 - Cancer risk assessment using genetic panel testing

T2 - Considerations for clinical application

AU - Hiraki, Susan

AU - Rinella, Erica S.

AU - Schnabel, Freya

AU - Oratz, Ruth

AU - Ostrer, Harry

PY - 2014

Y1 - 2014

N2 - With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines.

AB - With the completion of the Human Genome Project and the development of high throughput technologies, such as next-generation sequencing, the use of multiplex genetic testing, in which multiple genes are sequenced simultaneously to test for one or more conditions, is growing rapidly. Reflecting underlying heterogeneity where a broad range of genes confer risks for one or more cancers, the development of genetic cancer panels to assess these risks represents just one example of how multiplex testing is being applied clinically. There are a number of issues and challenges to consider when conducting genetic testing for cancer risk assessment, and these issues become exceedingly more complex when moving from the traditional single-gene approach to panel testing. Here, we address the practical considerations for clinical use of panel testing for breast, ovarian, and colon cancers, including the benefits, limitations and challenges, genetic counseling issues, and management guidelines.

KW - Breast cancer

KW - Cancer panels

KW - Colon cancer

KW - Ovarian cancer

KW - Risk assessment

UR - http://www.scopus.com/inward/record.url?scp=84904269657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904269657&partnerID=8YFLogxK

U2 - 10.1007/s10897-014-9695-6

DO - 10.1007/s10897-014-9695-6

M3 - Article

C2 - 24599651

AN - SCOPUS:84904269657

VL - 23

SP - 604

EP - 617

JO - Journal of Genetic Counseling

JF - Journal of Genetic Counseling

SN - 1059-7700

IS - 4

ER -