Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake

Derek M. Huffman, Maria S. Johnson, Amanda Watts, Ada Elgavish, Isam A. Eltoum, Tim R. Nagy

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Calorie restriction can inhibit or delay carcinogenesis, reportedly due to a reduction in calorie intake rather than by concurrent changes in body mass and/or composition. Our objective was to test the hypothesis that body mass and/or composition have an important effect, independent of energy intake, on the benefits or hazards associated with calorie restriction or overeating, respectively. In the first experiment, transgenic mice that spontaneously develop prostate cancer [transgenic adenocarcinoma of mouse prostate (TRAMP)] were housed at 27°C or 22°C and pair fed the same diet for 21 weeks (95% of ad libitum intake at 27°C). In the second experiment, TRAMP mice were housed at 27°C or 22°C and fed the same diet ad libitum for 21 weeks. Despite a similar calorie intake, pair-fed mice at 27°C (PF27) were heavier (28.3 ± 3.3 versus 17.6 ± 1.6 g at 21 weeks; P < 0.001; mean ± SD) and had greater fat (6.4 ± 2.1 versus 1.9 ± 0.3 g; P < 0.001) and lean mass (P < 0.001) than pair-fed mice at 22°C. Furthermore, PF27 mice had greater levels of serum leptin (P < 0.001), lower levels of adiponectin (P < 0.05), and a greater frequency of prostatic adenocarcinoma (P < 0.05). In contrast, ad libitum-fed mice housed at 22°C consumed ∼30% more calories than ad libitum-fed mice at 27°C, but there was no difference between groups in body composition or cancer progression. These results imply that the ability of calorie restriction to inhibit or delay cancer incidence and progression is mediated in part by changes in energy balance, body mass, and/or body composition rather than calorie intake per se, suggesting that excess calorie retention, rather than consumption, confers cancer risk.

Original languageEnglish (US)
Pages (from-to)417-424
Number of pages8
JournalCancer Research
Volume67
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Fingerprint

Body Composition
Transgenic Mice
Prostate
Adenocarcinoma
Eating
Neoplasms
Diet
Hyperphagia
Adiponectin
Leptin
Energy Intake
Prostatic Neoplasms
Carcinogenesis
Fats
Incidence
Serum

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake. / Huffman, Derek M.; Johnson, Maria S.; Watts, Amanda; Elgavish, Ada; Eltoum, Isam A.; Nagy, Tim R.

In: Cancer Research, Vol. 67, No. 1, 01.01.2007, p. 417-424.

Research output: Contribution to journalArticle

Huffman, Derek M. ; Johnson, Maria S. ; Watts, Amanda ; Elgavish, Ada ; Eltoum, Isam A. ; Nagy, Tim R. / Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake. In: Cancer Research. 2007 ; Vol. 67, No. 1. pp. 417-424.
@article{a73e12d6fe0e463ab82dd0e9dcfb31b8,
title = "Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake",
abstract = "Calorie restriction can inhibit or delay carcinogenesis, reportedly due to a reduction in calorie intake rather than by concurrent changes in body mass and/or composition. Our objective was to test the hypothesis that body mass and/or composition have an important effect, independent of energy intake, on the benefits or hazards associated with calorie restriction or overeating, respectively. In the first experiment, transgenic mice that spontaneously develop prostate cancer [transgenic adenocarcinoma of mouse prostate (TRAMP)] were housed at 27°C or 22°C and pair fed the same diet for 21 weeks (95{\%} of ad libitum intake at 27°C). In the second experiment, TRAMP mice were housed at 27°C or 22°C and fed the same diet ad libitum for 21 weeks. Despite a similar calorie intake, pair-fed mice at 27°C (PF27) were heavier (28.3 ± 3.3 versus 17.6 ± 1.6 g at 21 weeks; P < 0.001; mean ± SD) and had greater fat (6.4 ± 2.1 versus 1.9 ± 0.3 g; P < 0.001) and lean mass (P < 0.001) than pair-fed mice at 22°C. Furthermore, PF27 mice had greater levels of serum leptin (P < 0.001), lower levels of adiponectin (P < 0.05), and a greater frequency of prostatic adenocarcinoma (P < 0.05). In contrast, ad libitum-fed mice housed at 22°C consumed ∼30{\%} more calories than ad libitum-fed mice at 27°C, but there was no difference between groups in body composition or cancer progression. These results imply that the ability of calorie restriction to inhibit or delay cancer incidence and progression is mediated in part by changes in energy balance, body mass, and/or body composition rather than calorie intake per se, suggesting that excess calorie retention, rather than consumption, confers cancer risk.",
author = "Huffman, {Derek M.} and Johnson, {Maria S.} and Amanda Watts and Ada Elgavish and Eltoum, {Isam A.} and Nagy, {Tim R.}",
year = "2007",
month = "1",
day = "1",
doi = "10.1158/0008-5472.CAN-06-1244",
language = "English (US)",
volume = "67",
pages = "417--424",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "1",

}

TY - JOUR

T1 - Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake

AU - Huffman, Derek M.

AU - Johnson, Maria S.

AU - Watts, Amanda

AU - Elgavish, Ada

AU - Eltoum, Isam A.

AU - Nagy, Tim R.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Calorie restriction can inhibit or delay carcinogenesis, reportedly due to a reduction in calorie intake rather than by concurrent changes in body mass and/or composition. Our objective was to test the hypothesis that body mass and/or composition have an important effect, independent of energy intake, on the benefits or hazards associated with calorie restriction or overeating, respectively. In the first experiment, transgenic mice that spontaneously develop prostate cancer [transgenic adenocarcinoma of mouse prostate (TRAMP)] were housed at 27°C or 22°C and pair fed the same diet for 21 weeks (95% of ad libitum intake at 27°C). In the second experiment, TRAMP mice were housed at 27°C or 22°C and fed the same diet ad libitum for 21 weeks. Despite a similar calorie intake, pair-fed mice at 27°C (PF27) were heavier (28.3 ± 3.3 versus 17.6 ± 1.6 g at 21 weeks; P < 0.001; mean ± SD) and had greater fat (6.4 ± 2.1 versus 1.9 ± 0.3 g; P < 0.001) and lean mass (P < 0.001) than pair-fed mice at 22°C. Furthermore, PF27 mice had greater levels of serum leptin (P < 0.001), lower levels of adiponectin (P < 0.05), and a greater frequency of prostatic adenocarcinoma (P < 0.05). In contrast, ad libitum-fed mice housed at 22°C consumed ∼30% more calories than ad libitum-fed mice at 27°C, but there was no difference between groups in body composition or cancer progression. These results imply that the ability of calorie restriction to inhibit or delay cancer incidence and progression is mediated in part by changes in energy balance, body mass, and/or body composition rather than calorie intake per se, suggesting that excess calorie retention, rather than consumption, confers cancer risk.

AB - Calorie restriction can inhibit or delay carcinogenesis, reportedly due to a reduction in calorie intake rather than by concurrent changes in body mass and/or composition. Our objective was to test the hypothesis that body mass and/or composition have an important effect, independent of energy intake, on the benefits or hazards associated with calorie restriction or overeating, respectively. In the first experiment, transgenic mice that spontaneously develop prostate cancer [transgenic adenocarcinoma of mouse prostate (TRAMP)] were housed at 27°C or 22°C and pair fed the same diet for 21 weeks (95% of ad libitum intake at 27°C). In the second experiment, TRAMP mice were housed at 27°C or 22°C and fed the same diet ad libitum for 21 weeks. Despite a similar calorie intake, pair-fed mice at 27°C (PF27) were heavier (28.3 ± 3.3 versus 17.6 ± 1.6 g at 21 weeks; P < 0.001; mean ± SD) and had greater fat (6.4 ± 2.1 versus 1.9 ± 0.3 g; P < 0.001) and lean mass (P < 0.001) than pair-fed mice at 22°C. Furthermore, PF27 mice had greater levels of serum leptin (P < 0.001), lower levels of adiponectin (P < 0.05), and a greater frequency of prostatic adenocarcinoma (P < 0.05). In contrast, ad libitum-fed mice housed at 22°C consumed ∼30% more calories than ad libitum-fed mice at 27°C, but there was no difference between groups in body composition or cancer progression. These results imply that the ability of calorie restriction to inhibit or delay cancer incidence and progression is mediated in part by changes in energy balance, body mass, and/or body composition rather than calorie intake per se, suggesting that excess calorie retention, rather than consumption, confers cancer risk.

UR - http://www.scopus.com/inward/record.url?scp=33846422735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846422735&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-06-1244

DO - 10.1158/0008-5472.CAN-06-1244

M3 - Article

C2 - 17185379

AN - SCOPUS:33846422735

VL - 67

SP - 417

EP - 424

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 1

ER -