Cancer prevention and health benefices of traditionally consumed Borago Officinalis plants

María Dolores Lozano-Baena, Inmaculada Tasset, Andrés Muñoz-Serrano, Ángeles Alonso-Moraga, Antonio de Haro-Bailón

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Nowadays, healthy eating is increasing the demand of functional foods by societies as sources of bioactive products with healthy qualities. For this reason, we tested the safety of the consumption of Borago officinalis L. and its main phenolic components as well as the possibility of its use as a nutraceutical plant to help in cancer prevention. The in vivo Drosophila Somatic Mutation and Recombination Test (SMART) and in vitro HL-60 human cell systems were performed, as well-recognized methods for testing genotoxicity/cytotoxicity of bioactive compounds and plant products. B. officinalis and the tested compounds possess antigenotoxic activity. Moreover, B. officinalis wild type cultivar exerts the most antigenotoxic values. Cytotoxic effect was probed for both cultivars with IC50 values of 0.49 and 0.28 mg mL-1 for wild type and cultivated plants respectively, as well as their constituent rosmarinic acid and the assayed phenolic mixture (IC50 = 0.07 and 0.04 mM respectively). B. officinalis exerts DNA protection and anticarcinogenic effects as do its component rosmarinic acid and the mixture of the main phenolics presented in the plant. In conclusion, the results showed that B. officinalis may represent a high value plant for pleiotropic uses and support its consumption as a nutraceutical plant.

Original languageEnglish (US)
JournalNutrients
Volume8
Issue number1
DOIs
StatePublished - Jan 18 2016

Fingerprint

Borago
Borago officinalis
neoplasms
functional foods
Health
rosmarinic acid
Neoplasms
inhibitory concentration 50
cytotoxicity
Dietary Supplements
Inhibitory Concentration 50
somatic mutation
Anticarcinogenic Agents
plant products
genotoxicity
healthy diet
cultivars
anticarcinogenic activity
Functional Food
HL-60 Cells

Keywords

  • Borago officinalis
  • Cancer prevention
  • Dietary bioactives
  • Health
  • HL-60
  • Safety
  • SMART
  • Vegetables

ASJC Scopus subject areas

  • Food Science

Cite this

Lozano-Baena, M. D., Tasset, I., Muñoz-Serrano, A., Alonso-Moraga, Á., & de Haro-Bailón, A. (2016). Cancer prevention and health benefices of traditionally consumed Borago Officinalis plants. Nutrients, 8(1). https://doi.org/10.3390/nu8010048

Cancer prevention and health benefices of traditionally consumed Borago Officinalis plants. / Lozano-Baena, María Dolores; Tasset, Inmaculada; Muñoz-Serrano, Andrés; Alonso-Moraga, Ángeles; de Haro-Bailón, Antonio.

In: Nutrients, Vol. 8, No. 1, 18.01.2016.

Research output: Contribution to journalArticle

Lozano-Baena, MD, Tasset, I, Muñoz-Serrano, A, Alonso-Moraga, Á & de Haro-Bailón, A 2016, 'Cancer prevention and health benefices of traditionally consumed Borago Officinalis plants', Nutrients, vol. 8, no. 1. https://doi.org/10.3390/nu8010048
Lozano-Baena, María Dolores ; Tasset, Inmaculada ; Muñoz-Serrano, Andrés ; Alonso-Moraga, Ángeles ; de Haro-Bailón, Antonio. / Cancer prevention and health benefices of traditionally consumed Borago Officinalis plants. In: Nutrients. 2016 ; Vol. 8, No. 1.
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