Cancer incidence and mortality during the intervention and postintervention periods of the women's health initiative dietary modification trial

Cynthia A. Thomson, Linda Van Horn, Bette J. Caan, Aaron K. Aragaki, Rowan T. Chlebowski, JoAnn E. Manson, Thomas E. Rohan, Lesley F. Tinker, Lewis H. Kuller, Lifang Hou, Dorothy S. Lane, Karen C. Johnson, Mara Z. Vitolins, Ross L. Prentice

Research output: Contribution to journalArticle

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Abstract

Background: The Women's Health Initiative (WHI) low-fat (20% kcal) dietary modification (DM) trial (1993-2005) demonstrated a nonsignificant reduction in breast cancer, a nominally significant reduction in ovarian cancer, and no effect on other cancers (mean 8.3 years intervention). Consent to nonintervention follow-up was 83% (n = 37,858). This analysis was designed to assess postintervention cancer risk in women randomized to the low-fat diet (40%) versus usual diet comparison (60%).

Methods: Randomized, controlled low-fat diet intervention for prevention of breast and colorectal cancers conducted in 48,835 postmenopausal U.S. women, ages 50 to 79 years at 40 U.S. sites. Outcomes included total invasive cancer, breast cancer, and colorectal cancer, and cancer-specific and overall mortality.

Results: There were no intervention effects on invasive breast or colorectal cancer, other cancers, or cancer-specific or overall mortality during the postintervention period or the combined intervention and follow-up periods. For invasive breast cancer, the hazard ratios (HR) and 95% confidence interval (CI) were 0.92 (0.84-1.01) during intervention, 1.08 (0.94-1.24) during the postintervention period, and 0.97 (0.89-1.05) during cumulative follow-up. A reduced risk for estrogen receptor positive/progesterone receptor-negative tumors was demonstrated during follow-up. In women with higher baseline fat intake (quartile), point estimates of breast cancer risk were HR, 0.76 (95% CI, 0.62-0.92) during intervention versus HR, 1.11 (95% CI, 0.84-1.4) during postintervention follow-up (Pdiff = 0.03).

Conclusions: Dietary fat intake increased postintervention in intervention women; no long-term reduction in cancer risk or mortality was shown in the WHI DM trial.

Impact: Dietary advisement to reduce fat for cancer prevention after menopause generally was not supported by the WHI DM trial.

Original languageEnglish (US)
Pages (from-to)2924-2935
Number of pages12
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2014

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Diet Therapy
Women's Health
Breast Neoplasms
Mortality
Incidence
Neoplasms
Colorectal Neoplasms
Fat-Restricted Diet
Fats
Confidence Intervals
Dietary Fats
Progesterone Receptors
Menopause
Estrogen Receptors
Ovarian Neoplasms
Diet

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Cancer incidence and mortality during the intervention and postintervention periods of the women's health initiative dietary modification trial. / Thomson, Cynthia A.; Van Horn, Linda; Caan, Bette J.; Aragaki, Aaron K.; Chlebowski, Rowan T.; Manson, JoAnn E.; Rohan, Thomas E.; Tinker, Lesley F.; Kuller, Lewis H.; Hou, Lifang; Lane, Dorothy S.; Johnson, Karen C.; Vitolins, Mara Z.; Prentice, Ross L.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 23, No. 12, 01.12.2014, p. 2924-2935.

Research output: Contribution to journalArticle

Thomson, CA, Van Horn, L, Caan, BJ, Aragaki, AK, Chlebowski, RT, Manson, JE, Rohan, TE, Tinker, LF, Kuller, LH, Hou, L, Lane, DS, Johnson, KC, Vitolins, MZ & Prentice, RL 2014, 'Cancer incidence and mortality during the intervention and postintervention periods of the women's health initiative dietary modification trial', Cancer Epidemiology Biomarkers and Prevention, vol. 23, no. 12, pp. 2924-2935. https://doi.org/10.1158/1055-9965.EPI-14-0922
Thomson, Cynthia A. ; Van Horn, Linda ; Caan, Bette J. ; Aragaki, Aaron K. ; Chlebowski, Rowan T. ; Manson, JoAnn E. ; Rohan, Thomas E. ; Tinker, Lesley F. ; Kuller, Lewis H. ; Hou, Lifang ; Lane, Dorothy S. ; Johnson, Karen C. ; Vitolins, Mara Z. ; Prentice, Ross L. / Cancer incidence and mortality during the intervention and postintervention periods of the women's health initiative dietary modification trial. In: Cancer Epidemiology Biomarkers and Prevention. 2014 ; Vol. 23, No. 12. pp. 2924-2935.
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T1 - Cancer incidence and mortality during the intervention and postintervention periods of the women's health initiative dietary modification trial

AU - Thomson, Cynthia A.

AU - Van Horn, Linda

AU - Caan, Bette J.

AU - Aragaki, Aaron K.

AU - Chlebowski, Rowan T.

AU - Manson, JoAnn E.

AU - Rohan, Thomas E.

AU - Tinker, Lesley F.

AU - Kuller, Lewis H.

AU - Hou, Lifang

AU - Lane, Dorothy S.

AU - Johnson, Karen C.

AU - Vitolins, Mara Z.

AU - Prentice, Ross L.

PY - 2014/12/1

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N2 - Background: The Women's Health Initiative (WHI) low-fat (20% kcal) dietary modification (DM) trial (1993-2005) demonstrated a nonsignificant reduction in breast cancer, a nominally significant reduction in ovarian cancer, and no effect on other cancers (mean 8.3 years intervention). Consent to nonintervention follow-up was 83% (n = 37,858). This analysis was designed to assess postintervention cancer risk in women randomized to the low-fat diet (40%) versus usual diet comparison (60%).Methods: Randomized, controlled low-fat diet intervention for prevention of breast and colorectal cancers conducted in 48,835 postmenopausal U.S. women, ages 50 to 79 years at 40 U.S. sites. Outcomes included total invasive cancer, breast cancer, and colorectal cancer, and cancer-specific and overall mortality.Results: There were no intervention effects on invasive breast or colorectal cancer, other cancers, or cancer-specific or overall mortality during the postintervention period or the combined intervention and follow-up periods. For invasive breast cancer, the hazard ratios (HR) and 95% confidence interval (CI) were 0.92 (0.84-1.01) during intervention, 1.08 (0.94-1.24) during the postintervention period, and 0.97 (0.89-1.05) during cumulative follow-up. A reduced risk for estrogen receptor positive/progesterone receptor-negative tumors was demonstrated during follow-up. In women with higher baseline fat intake (quartile), point estimates of breast cancer risk were HR, 0.76 (95% CI, 0.62-0.92) during intervention versus HR, 1.11 (95% CI, 0.84-1.4) during postintervention follow-up (Pdiff = 0.03).Conclusions: Dietary fat intake increased postintervention in intervention women; no long-term reduction in cancer risk or mortality was shown in the WHI DM trial.Impact: Dietary advisement to reduce fat for cancer prevention after menopause generally was not supported by the WHI DM trial.

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