Cancer in World Trade Center responders: Findings from multiple cohorts and options for future study

Paolo Boffetta, Rachel Zeig-Owens, Sylvan Wallenstein, Jiehui Li, Robert Brackbill, James Cone, Mark Farfel, William Holden, Roberto Lucchini, Mayris P. Webber, David Prezant, Steven D. Stellman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Three longitudinal studies of cancer incidence in varied populations of World Trade Center responders have been conducted. Methods: We compared the design and results of the three studies. Results: Separate analyses of these cohorts revealed excess cancer incidence in responders for all cancers combined and for cancers of the thyroid and prostate. Methodological dissimilarities included recruitment strategies, source of cohort members, demographic characteristics, overlap between cohorts, assessment of WTC and other occupational exposures and confounders, methods and duration of follow-up, approaches for statistical analysis, and latency analyses. Conclusions: The presence of three cohorts strengthens the effort of identifying and quantifying the cancer risk; the heterogeneity in design might increase sensitivity to the identification of cancers potentially associated with exposure. The presence and magnitude of an increased cancer risk remains to be fully elucidated. Continued long-term follow up with minimal longitudinal dropout is crucial to achieve this goal.

Original languageEnglish (US)
Pages (from-to)96-105
Number of pages10
JournalAmerican Journal of Industrial Medicine
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Neoplasms
Incidence
Occupational Exposure
Thyroid Neoplasms
Longitudinal Studies
Prostatic Neoplasms
Cohort Studies
Demography
Population

Keywords

  • Cancer
  • Cohort study
  • Epidemiology
  • Surveillance
  • World Trade Center

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Cancer in World Trade Center responders : Findings from multiple cohorts and options for future study. / Boffetta, Paolo; Zeig-Owens, Rachel; Wallenstein, Sylvan; Li, Jiehui; Brackbill, Robert; Cone, James; Farfel, Mark; Holden, William; Lucchini, Roberto; Webber, Mayris P.; Prezant, David; Stellman, Steven D.

In: American Journal of Industrial Medicine, Vol. 59, No. 2, 01.02.2016, p. 96-105.

Research output: Contribution to journalArticle

Boffetta, P, Zeig-Owens, R, Wallenstein, S, Li, J, Brackbill, R, Cone, J, Farfel, M, Holden, W, Lucchini, R, Webber, MP, Prezant, D & Stellman, SD 2016, 'Cancer in World Trade Center responders: Findings from multiple cohorts and options for future study', American Journal of Industrial Medicine, vol. 59, no. 2, pp. 96-105. https://doi.org/10.1002/ajim.22555
Boffetta, Paolo ; Zeig-Owens, Rachel ; Wallenstein, Sylvan ; Li, Jiehui ; Brackbill, Robert ; Cone, James ; Farfel, Mark ; Holden, William ; Lucchini, Roberto ; Webber, Mayris P. ; Prezant, David ; Stellman, Steven D. / Cancer in World Trade Center responders : Findings from multiple cohorts and options for future study. In: American Journal of Industrial Medicine. 2016 ; Vol. 59, No. 2. pp. 96-105.
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