Cancer after pre-eclampsia: Follow up of the Jerusalem perinatal study cohort

Ora Paltiel, Yehiel Friedlander, Efrat Tiram, Micha Barchana, Xiaonan (Nan) Xue, Susan Harlap

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: To compare the incidence of cancer among women with and without a history of pre-eclampsia. Design: Cohort study. Setting: Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-76. Participants: 37 033 women. Main outcome measures: Age adjusted and multivariable adjusted hazard ratios for cancer incidence for the entire cohort and for women who were primiparous at study entry. Results: Cancer developed in 91 women who had pre-eclampsia and 2204 who did not (hazard ratio 1.27, 95% confidence interval 1.03 to 1.57). The risk of site specific cancers was increased, particularly of the stomach, ovary epithelium, breast, and lung or larynx. The incidence of cancer of the stomach, breast, ovary, kidney, and lung or larynx was increased in primiparous women at study entry who had a history of pre-eclampsia. Conclusions: A history of pre-eclampsia is associated with increases in overall risk of cancer and incidence at several sites. This may be explained by environmental and genetic factors common to the development of pre-eclampsia and cancer in this population.

Original languageEnglish (US)
Pages (from-to)919-921
Number of pages3
JournalBritish Medical Journal
Volume328
Issue number7445
StatePublished - Apr 17 2004

Fingerprint

Pre-Eclampsia
Cohort Studies
Neoplasms
Incidence
Larynx
Ovary
Lung
Stomach Neoplasms
Stomach
Breast
Epithelium
Outcome Assessment (Health Care)
Confidence Intervals
Breast Neoplasms
Kidney
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Paltiel, O., Friedlander, Y., Tiram, E., Barchana, M., Xue, X. N., & Harlap, S. (2004). Cancer after pre-eclampsia: Follow up of the Jerusalem perinatal study cohort. British Medical Journal, 328(7445), 919-921.

Cancer after pre-eclampsia : Follow up of the Jerusalem perinatal study cohort. / Paltiel, Ora; Friedlander, Yehiel; Tiram, Efrat; Barchana, Micha; Xue, Xiaonan (Nan); Harlap, Susan.

In: British Medical Journal, Vol. 328, No. 7445, 17.04.2004, p. 919-921.

Research output: Contribution to journalArticle

Paltiel, O, Friedlander, Y, Tiram, E, Barchana, M, Xue, XN & Harlap, S 2004, 'Cancer after pre-eclampsia: Follow up of the Jerusalem perinatal study cohort', British Medical Journal, vol. 328, no. 7445, pp. 919-921.
Paltiel O, Friedlander Y, Tiram E, Barchana M, Xue XN, Harlap S. Cancer after pre-eclampsia: Follow up of the Jerusalem perinatal study cohort. British Medical Journal. 2004 Apr 17;328(7445):919-921.
Paltiel, Ora ; Friedlander, Yehiel ; Tiram, Efrat ; Barchana, Micha ; Xue, Xiaonan (Nan) ; Harlap, Susan. / Cancer after pre-eclampsia : Follow up of the Jerusalem perinatal study cohort. In: British Medical Journal. 2004 ; Vol. 328, No. 7445. pp. 919-921.
@article{5a7ccfe97b014009bed5f7f14e8773e6,
title = "Cancer after pre-eclampsia: Follow up of the Jerusalem perinatal study cohort",
abstract = "Objective: To compare the incidence of cancer among women with and without a history of pre-eclampsia. Design: Cohort study. Setting: Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-76. Participants: 37 033 women. Main outcome measures: Age adjusted and multivariable adjusted hazard ratios for cancer incidence for the entire cohort and for women who were primiparous at study entry. Results: Cancer developed in 91 women who had pre-eclampsia and 2204 who did not (hazard ratio 1.27, 95{\%} confidence interval 1.03 to 1.57). The risk of site specific cancers was increased, particularly of the stomach, ovary epithelium, breast, and lung or larynx. The incidence of cancer of the stomach, breast, ovary, kidney, and lung or larynx was increased in primiparous women at study entry who had a history of pre-eclampsia. Conclusions: A history of pre-eclampsia is associated with increases in overall risk of cancer and incidence at several sites. This may be explained by environmental and genetic factors common to the development of pre-eclampsia and cancer in this population.",
author = "Ora Paltiel and Yehiel Friedlander and Efrat Tiram and Micha Barchana and Xue, {Xiaonan (Nan)} and Susan Harlap",
year = "2004",
month = "4",
day = "17",
language = "English (US)",
volume = "328",
pages = "919--921",
journal = "BMJ (Online)",
issn = "0959-8146",
publisher = "BMJ Publishing Group",
number = "7445",

}

TY - JOUR

T1 - Cancer after pre-eclampsia

T2 - Follow up of the Jerusalem perinatal study cohort

AU - Paltiel, Ora

AU - Friedlander, Yehiel

AU - Tiram, Efrat

AU - Barchana, Micha

AU - Xue, Xiaonan (Nan)

AU - Harlap, Susan

PY - 2004/4/17

Y1 - 2004/4/17

N2 - Objective: To compare the incidence of cancer among women with and without a history of pre-eclampsia. Design: Cohort study. Setting: Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-76. Participants: 37 033 women. Main outcome measures: Age adjusted and multivariable adjusted hazard ratios for cancer incidence for the entire cohort and for women who were primiparous at study entry. Results: Cancer developed in 91 women who had pre-eclampsia and 2204 who did not (hazard ratio 1.27, 95% confidence interval 1.03 to 1.57). The risk of site specific cancers was increased, particularly of the stomach, ovary epithelium, breast, and lung or larynx. The incidence of cancer of the stomach, breast, ovary, kidney, and lung or larynx was increased in primiparous women at study entry who had a history of pre-eclampsia. Conclusions: A history of pre-eclampsia is associated with increases in overall risk of cancer and incidence at several sites. This may be explained by environmental and genetic factors common to the development of pre-eclampsia and cancer in this population.

AB - Objective: To compare the incidence of cancer among women with and without a history of pre-eclampsia. Design: Cohort study. Setting: Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-76. Participants: 37 033 women. Main outcome measures: Age adjusted and multivariable adjusted hazard ratios for cancer incidence for the entire cohort and for women who were primiparous at study entry. Results: Cancer developed in 91 women who had pre-eclampsia and 2204 who did not (hazard ratio 1.27, 95% confidence interval 1.03 to 1.57). The risk of site specific cancers was increased, particularly of the stomach, ovary epithelium, breast, and lung or larynx. The incidence of cancer of the stomach, breast, ovary, kidney, and lung or larynx was increased in primiparous women at study entry who had a history of pre-eclampsia. Conclusions: A history of pre-eclampsia is associated with increases in overall risk of cancer and incidence at several sites. This may be explained by environmental and genetic factors common to the development of pre-eclampsia and cancer in this population.

UR - http://www.scopus.com/inward/record.url?scp=1942510619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1942510619&partnerID=8YFLogxK

M3 - Article

C2 - 15003975

AN - SCOPUS:1942510619

VL - 328

SP - 919

EP - 921

JO - BMJ (Online)

JF - BMJ (Online)

SN - 0959-8146

IS - 7445

ER -