Can risk factor screening predict Hepatitis C antibody reactivity?

Urania Magriples, Peter S. Bernstein, Edward Snyder, Joshua A. Copel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The object of this study was to investigate the prevalence of Hepatitis C Virus (HCV) by second-generation testing and to determine the effectiveness of risk factor-guided screening. We performed a prospective study of HCV exposure determined by second-generation enzyme-linked immunoadsorbent assay (ELISA) and confirmed by radioimmunoblot assay (RIBA). Risk factors (RF) were interpreted by univariate and multivariate analyses. Eight hundred eighty- six consecutive patients were tested for HCV over a 1-year period; 34 women tested positive for HCV and 32 were confirmed by RIBA (prevalence 3.6%). Forty-nine percent of women had at least one RF. Age, intravenous drug use, history of hepatitis strongly correlated with HCV (p <0.001). RF screening had a sensitivity of 81%. Twenty-one percent of women with HCV had no RF. The absence of any RF had a negative predictive value of 98.7%. RF screening is effective in identifying patients at low risk for HCV.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalAmerican Journal of Perinatology
Volume15
Issue number6
StatePublished - Jun 1998
Externally publishedYes

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Hepatitis C Antibodies
Hepacivirus
Immunosorbents
Hepatitis
Multivariate Analysis
Prospective Studies
Enzymes
Pharmaceutical Preparations

Keywords

  • Hepatitis C
  • Hepatitis C epidemiology
  • Hepatitis C screening

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Can risk factor screening predict Hepatitis C antibody reactivity? / Magriples, Urania; Bernstein, Peter S.; Snyder, Edward; Copel, Joshua A.

In: American Journal of Perinatology, Vol. 15, No. 6, 06.1998, p. 395-398.

Research output: Contribution to journalArticle

Magriples, U, Bernstein, PS, Snyder, E & Copel, JA 1998, 'Can risk factor screening predict Hepatitis C antibody reactivity?', American Journal of Perinatology, vol. 15, no. 6, pp. 395-398.
Magriples, Urania ; Bernstein, Peter S. ; Snyder, Edward ; Copel, Joshua A. / Can risk factor screening predict Hepatitis C antibody reactivity?. In: American Journal of Perinatology. 1998 ; Vol. 15, No. 6. pp. 395-398.
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