Abstract
The object of this study was to investigate the prevalence of Hepatitis C Virus (HCV) by second-generation testing and to determine the effectiveness of risk factor-guided screening. We performed a prospective study of HCV exposure determined by second-generation enzyme-linked immunoadsorbent assay (ELISA) and confirmed by radioimmunoblot assay (RIBA). Risk factors (RF) were interpreted by univariate and multivariate analyses. Eight hundred eighty- six consecutive patients were tested for HCV over a 1-year period; 34 women tested positive for HCV and 32 were confirmed by RIBA (prevalence 3.6%). Forty-nine percent of women had at least one RF. Age, intravenous drug use, history of hepatitis strongly correlated with HCV (p <0.001). RF screening had a sensitivity of 81%. Twenty-one percent of women with HCV had no RF. The absence of any RF had a negative predictive value of 98.7%. RF screening is effective in identifying patients at low risk for HCV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 395-398 |
| Number of pages | 4 |
| Journal | American Journal of Perinatology |
| Volume | 15 |
| Issue number | 6 |
| State | Published - Jun 1998 |
| Externally published | Yes |
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Keywords
- Hepatitis C
- Hepatitis C epidemiology
- Hepatitis C screening
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
Cite this
Can risk factor screening predict Hepatitis C antibody reactivity? / Magriples, Urania; Bernstein, Peter S.; Snyder, Edward; Copel, Joshua A.
In: American Journal of Perinatology, Vol. 15, No. 6, 06.1998, p. 395-398.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Can risk factor screening predict Hepatitis C antibody reactivity?
AU - Magriples, Urania
AU - Bernstein, Peter S.
AU - Snyder, Edward
AU - Copel, Joshua A.
PY - 1998/6
Y1 - 1998/6
N2 - The object of this study was to investigate the prevalence of Hepatitis C Virus (HCV) by second-generation testing and to determine the effectiveness of risk factor-guided screening. We performed a prospective study of HCV exposure determined by second-generation enzyme-linked immunoadsorbent assay (ELISA) and confirmed by radioimmunoblot assay (RIBA). Risk factors (RF) were interpreted by univariate and multivariate analyses. Eight hundred eighty- six consecutive patients were tested for HCV over a 1-year period; 34 women tested positive for HCV and 32 were confirmed by RIBA (prevalence 3.6%). Forty-nine percent of women had at least one RF. Age, intravenous drug use, history of hepatitis strongly correlated with HCV (p <0.001). RF screening had a sensitivity of 81%. Twenty-one percent of women with HCV had no RF. The absence of any RF had a negative predictive value of 98.7%. RF screening is effective in identifying patients at low risk for HCV.
AB - The object of this study was to investigate the prevalence of Hepatitis C Virus (HCV) by second-generation testing and to determine the effectiveness of risk factor-guided screening. We performed a prospective study of HCV exposure determined by second-generation enzyme-linked immunoadsorbent assay (ELISA) and confirmed by radioimmunoblot assay (RIBA). Risk factors (RF) were interpreted by univariate and multivariate analyses. Eight hundred eighty- six consecutive patients were tested for HCV over a 1-year period; 34 women tested positive for HCV and 32 were confirmed by RIBA (prevalence 3.6%). Forty-nine percent of women had at least one RF. Age, intravenous drug use, history of hepatitis strongly correlated with HCV (p <0.001). RF screening had a sensitivity of 81%. Twenty-one percent of women with HCV had no RF. The absence of any RF had a negative predictive value of 98.7%. RF screening is effective in identifying patients at low risk for HCV.
KW - Hepatitis C
KW - Hepatitis C epidemiology
KW - Hepatitis C screening
UR - http://www.scopus.com/inward/record.url?scp=0031820759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031820759&partnerID=8YFLogxK
M3 - Article
C2 - 9722062
AN - SCOPUS:0031820759
VL - 15
SP - 395
EP - 398
JO - American Journal of Perinatology
JF - American Journal of Perinatology
SN - 0735-1631
IS - 6
ER -