Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis β-lactamase BlaC lead to clavulanate resistance? A biochemical rationale for the use of β-lactam-β-lactamase inhibitor combinations

Sebastian G. Kurz, Kerstin A. Wolff, Saugata Hazra, Christopher R. Bethel, Andrea M. Hujer, Kerri M. Smith, Yan Xu, Lee W. Tremblay, John S. Blanchard, Liem Nguyen, Robert A. Bonomo

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