TY - JOUR
T1 - Can Berberine Serve as a New Therapy for Parkinson’s Disease?
AU - Dadgostar, Ehsan
AU - Moghanlou, Mahsa
AU - Parvaresh, Mehrnoosh
AU - Mohammadi, Salimeh
AU - Khandan, Mohammadali
AU - Aschner, Michael
AU - Mirzaei, Hamed
AU - Tamtaji, Omid Reza
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/8
Y1 - 2022/8
N2 - Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration and deposition of alpha-synuclein. Mechanisms associated with PD etiology include oxidative stress, apoptosis, autophagy, and abnormalities in neurotransmission, to name a few. Drugs used to treat PD have shown significant limitations in their efficacy. Therefore, recent focus has been placed on the potential of active plant ingredients as alternative, complementary, and efficient treatments. Berberine is an isoquinoline alkaloid that has shown promise as a pharmacological treatment in PD, given its ability to modulate several molecular pathway associated with the disease. Here, we review contemporary knowledge supporting the need to further characterize berberine as a potential treatment for PD.
AB - Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration and deposition of alpha-synuclein. Mechanisms associated with PD etiology include oxidative stress, apoptosis, autophagy, and abnormalities in neurotransmission, to name a few. Drugs used to treat PD have shown significant limitations in their efficacy. Therefore, recent focus has been placed on the potential of active plant ingredients as alternative, complementary, and efficient treatments. Berberine is an isoquinoline alkaloid that has shown promise as a pharmacological treatment in PD, given its ability to modulate several molecular pathway associated with the disease. Here, we review contemporary knowledge supporting the need to further characterize berberine as a potential treatment for PD.
KW - Apoptosis
KW - Autophagy
KW - Berberine
KW - Oxidative stress
KW - Parkinson’s disease
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U2 - 10.1007/s12640-022-00526-2
DO - 10.1007/s12640-022-00526-2
M3 - Review article
C2 - 35666433
AN - SCOPUS:85131401065
SN - 1029-8428
VL - 40
SP - 1096
EP - 1102
JO - Neurotoxicity Research
JF - Neurotoxicity Research
IS - 4
ER -