Can Berberine Serve as a New Therapy for Parkinson’s Disease?

Ehsan Dadgostar, Mahsa Moghanlou, Mehrnoosh Parvaresh, Salimeh Mohammadi, Mohammadali Khandan, Michael Aschner, Hamed Mirzaei, Omid Reza Tamtaji

Research output: Contribution to journalReview articlepeer-review

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neurodegeneration and deposition of alpha-synuclein. Mechanisms associated with PD etiology include oxidative stress, apoptosis, autophagy, and abnormalities in neurotransmission, to name a few. Drugs used to treat PD have shown significant limitations in their efficacy. Therefore, recent focus has been placed on the potential of active plant ingredients as alternative, complementary, and efficient treatments. Berberine is an isoquinoline alkaloid that has shown promise as a pharmacological treatment in PD, given its ability to modulate several molecular pathway associated with the disease. Here, we review contemporary knowledge supporting the need to further characterize berberine as a potential treatment for PD.

Original languageEnglish (US)
Pages (from-to)1096-1102
Number of pages7
JournalNeurotoxicity Research
Volume40
Issue number4
DOIs
StatePublished - Aug 2022

Keywords

  • Apoptosis
  • Autophagy
  • Berberine
  • Oxidative stress
  • Parkinson’s disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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