Abstract
Background:Tamoxifen (TX), a selective estrogen receptor modulator, enhances glutamate transporter (GLT-1) expression in astrocytes. Results:TX up-regulated GLT-1 expression via the CREB and NF-κB pathways. Conclusion:TX enhanced GLT-1 expression at the transcriptional level. Significance:Understanding the mechanisms of TX action on GLT-1 will contribute to the development of neuroprotectants against excitotoxicity.
Original language | English (US) |
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Pages (from-to) | 28975-28986 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 40 |
DOIs | |
State | Published - Oct 4 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology