CAMP response element-binding protein (CREB) and nuclear factorκb mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes

Pratap Karki, Anton Webb, Keisha Smith, Kyuwon Lee, Deok Soo Son, Michael Aschner, Eunsook Lee

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background:Tamoxifen (TX), a selective estrogen receptor modulator, enhances glutamate transporter (GLT-1) expression in astrocytes. Results:TX up-regulated GLT-1 expression via the CREB and NF-κB pathways. Conclusion:TX enhanced GLT-1 expression at the transcriptional level. Significance:Understanding the mechanisms of TX action on GLT-1 will contribute to the development of neuroprotectants against excitotoxicity.

Original languageEnglish (US)
Pages (from-to)28975-28986
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013
Externally publishedYes

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Amino Acid Transport System X-AG
Response Elements
Tamoxifen
Astrocytes
Rats
Carrier Proteins
Up-Regulation
Selective Estrogen Receptor Modulators
Neuroprotective Agents

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

CAMP response element-binding protein (CREB) and nuclear factorκb mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes. / Karki, Pratap; Webb, Anton; Smith, Keisha; Lee, Kyuwon; Son, Deok Soo; Aschner, Michael; Lee, Eunsook.

In: Journal of Biological Chemistry, Vol. 288, No. 40, 04.10.2013, p. 28975-28986.

Research output: Contribution to journalArticle

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AU - Aschner, Michael

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