Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice

Ping Huang, Shoufeng Li, Mengle Shao, Qibin Qi, Feng Zhao, Jia You, Ting Mao, Wenjun Li, Zhen Yan, Yong Liu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance. Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression. Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal. Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.

Original languageEnglish (US)
Article number59
JournalNutrition and Metabolism
Volume7
DOIs
StatePublished - 2010
Externally publishedYes

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High Fat Diet
Insulin Resistance
Adipose Tissue
Anti-Inflammatory Agents
Obesity
Diet
Fat-Restricted Diet
Fats
Cytokines
White Adipose Tissue
Inbred C57BL Mouse
Running
Gene Expression
Liver

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. / Huang, Ping; Li, Shoufeng; Shao, Mengle; Qi, Qibin; Zhao, Feng; You, Jia; Mao, Ting; Li, Wenjun; Yan, Zhen; Liu, Yong.

In: Nutrition and Metabolism, Vol. 7, 59, 2010.

Research output: Contribution to journalArticle

Huang, Ping ; Li, Shoufeng ; Shao, Mengle ; Qi, Qibin ; Zhao, Feng ; You, Jia ; Mao, Ting ; Li, Wenjun ; Yan, Zhen ; Liu, Yong. / Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. In: Nutrition and Metabolism. 2010 ; Vol. 7.
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AU - Huang, Ping

AU - Li, Shoufeng

AU - Shao, Mengle

AU - Qi, Qibin

AU - Zhao, Feng

AU - You, Jia

AU - Mao, Ting

AU - Li, Wenjun

AU - Yan, Zhen

AU - Liu, Yong

PY - 2010

Y1 - 2010

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