TY - JOUR
T1 - Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice
AU - Huang, Ping
AU - Li, Shoufeng
AU - Shao, Mengle
AU - Qi, Qibin
AU - Zhao, Feng
AU - You, Jia
AU - Mao, Ting
AU - Li, Wenjun
AU - Yan, Zhen
AU - Liu, Yong
N1 - Funding Information:
We thank Jun Shen for technical assistance. This study was supported by grants from National Natural Science Foundation (No. 30988002, 90713027 and 30830033), the Ministry of Science and Technology (973 Program 2006CB503900 and 2007CB947100), Chinese Academy of Sciences (The Knowledge Innovation Programs No. KSCX1-YW-02 and KSCX2-YW-R-115, and the CAS/SAFEA International Partnership Program), Science and Technology Commission of Shanghai Municipality (No. 08dj1400601) to YL and WL, and by American Diabetes Association Research Award 7-06-RA-165 to ZY.
PY - 2010
Y1 - 2010
N2 - Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance. Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression. Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal. Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.
AB - Background: Calorie restriction (CR) and endurance exercise are known to attenuate obesity and improve the metabolic syndrome. The aim of this study was to directly compare the effects of CR and endurance exercise in a mouse model of diet-induced obesity and insulin resistance. Methods: Adult male C57BL/6N mice were randomly assigned and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat), low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise (HE), and high-fat diet with a combination of 30% calorie restriction and exercise (HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses and pro-inflammatory cytokine gene expression. Results: Endurance exercise significantly attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced metabolic abnormalities. A combination of CR and endurance exercise further reduced obesity and insulin resistance under the condition of high-fat diet. CR and endurance exercise each potently suppressed the expression of inflammatory cytokines in white adipose tissues with additive effects when combined, but the effects of diet and exercise interventions in the liver were moderate to minimal. Conclusions: CR and endurance exercise share a potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance.
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U2 - 10.1186/1743-7075-7-59
DO - 10.1186/1743-7075-7-59
M3 - Article
C2 - 20633301
AN - SCOPUS:77954554653
SN - 1743-7075
VL - 7
JO - Nutrition and Metabolism
JF - Nutrition and Metabolism
M1 - 59
ER -