Calcium is necessary in the cell response to EM fields

Rouzan Karabakhtsian, Natasha Broude, Natalia Shalts, Serguei Kochlatyia, Reba Goodman, Ann S. Henderson

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Previous research showed that exposure of human HL-60 cells to extremely low frequency electromagnetic fields increases the steady-state levels of some mRNAs. Modifications in calcium flux have been suggested as a means of amplifying electromagnetic signals, and induced changes in calcium influx could hypothetically lead to gene activation. The present experiments tested the role of calcium in the response of cells to electromagnetic fields. Steady state transcript levels for c-fos and c-myc were determined under conditions of low extracellular calcium. The present study confirms that calcium plays a role in the response of cells to electromagnetic fields.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalFEBS Letters
Volume349
Issue number1
DOIs
StatePublished - Jul 25 1994
Externally publishedYes

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Keywords

  • Calcium
  • Extremely low frequency (elf) electromagnetic (EM) fields
  • RNA transcript

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Karabakhtsian, R., Broude, N., Shalts, N., Kochlatyia, S., Goodman, R., & Henderson, A. S. (1994). Calcium is necessary in the cell response to EM fields. FEBS Letters, 349(1), 1-6. https://doi.org/10.1016/0014-5793(94)00618-0