TY - JOUR
T1 - Calcitonin gene-related peptide in hepatorenal syndrome
T2 - A possible mediator of peripheral vasodilation?
AU - Gupta, Sanjeev
AU - Morgan, Timothy R.
AU - Gordan, Gilbert S.
PY - 1992/3
Y1 - 1992/3
N2 - In advanced cirrhosis and hepatorenal syndrome, peripheral vasodilation is a prominent feature and may be pathophysiologically relevant. To determine whether the potent vasodilator, calcitonin gene-related peptide (CGRP), circulates at abnormal levels in patients with these disorders, we observed eight patients with alcoholic cirrhosis and hepatorenal syndrome, seven with alcoholic cirrhosis and ascites without hepatorenal syndrome, and 10 healthy controls. Plasma CGRP levels were higher in patients with alcoholic cirrhosis and hepatorenal syndrome (364 ± 166 pg/ml) than in healthy controls (143 ± 54 pg/ml, p < 0.01). In patients with cirrhosis and ascites without hepatorenal syndrome, plasma CGRP levels were less elevated (291 ± 257 pg/ml, NS). The identity of immunoreactive CGRP and synthetic hCGRP was confirmed by high performance liquid chromatography. These results suggest that CGRP may play a role in hepatorenal syndrome. However, to establish whether circulating CGRP contributes to the hemodynamic change in hepatorenal syndrome requires study of a larger number of patients and additional control groups.
AB - In advanced cirrhosis and hepatorenal syndrome, peripheral vasodilation is a prominent feature and may be pathophysiologically relevant. To determine whether the potent vasodilator, calcitonin gene-related peptide (CGRP), circulates at abnormal levels in patients with these disorders, we observed eight patients with alcoholic cirrhosis and hepatorenal syndrome, seven with alcoholic cirrhosis and ascites without hepatorenal syndrome, and 10 healthy controls. Plasma CGRP levels were higher in patients with alcoholic cirrhosis and hepatorenal syndrome (364 ± 166 pg/ml) than in healthy controls (143 ± 54 pg/ml, p < 0.01). In patients with cirrhosis and ascites without hepatorenal syndrome, plasma CGRP levels were less elevated (291 ± 257 pg/ml, NS). The identity of immunoreactive CGRP and synthetic hCGRP was confirmed by high performance liquid chromatography. These results suggest that CGRP may play a role in hepatorenal syndrome. However, to establish whether circulating CGRP contributes to the hemodynamic change in hepatorenal syndrome requires study of a larger number of patients and additional control groups.
KW - Calcitonin gene-related peptide
KW - Cirrhosis
KW - Hepatorenal syndrome
KW - Vasodilation
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U2 - 10.1097/00004836-199203000-00010
DO - 10.1097/00004836-199203000-00010
M3 - Article
C2 - 1532610
AN - SCOPUS:0026537191
SN - 0192-0790
VL - 14
SP - 122
EP - 126
JO - Journal of clinical gastroenterology
JF - Journal of clinical gastroenterology
IS - 2
ER -