Calcitonin gene-related peptide immunoreactivity in familial amyotrophic lateral sclerosis

Takeo Kato, Asao Hirano, Hideo Manaka, Hajime Sasaki, Tadashi Katagiri, Toru Kawanami, Yukihiro Shikama, Tomomi Seino, Hideo Sasaki

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9 Scopus citations

Abstract

The lumbar cords from 3 cases of familial amyotrophic lateral sclerosis (fALS), one case of vincristine neuropathy, and two control cases were examined with an antiserum to calcitonin gene-related peptide (CGRP). The anti-CGRP intensely labelled the spinal posterior horns in all cases. In the anterior horns, several perikarya and cord-like neuritic swellings, mostly axons, were labelled with the antibody in the fALS cases, whereas CGRP-positive structures were extremely rare in the cases other than fALS. It is possible that the accumulation of CGRP in the proximal axonal swellings and perikarya may result from entrapment of CGRP during the anterograde axonal transport, causing loss of, or decrease in, CGRP at the neuromuscular junction and producing weakness and atrophy of the muscles.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalNeuroscience Letters
Volume133
Issue number2
DOIs
StatePublished - Dec 9 1991

Keywords

  • Anterior horn cell
  • Calcitonin gene-related peptide
  • Central chromatolysis
  • Cord-like neuritic swelling
  • Familial amyotrophic lateral sclerosis
  • Neurofilament
  • Spinal cord
  • Ubiquitin

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kato, T., Hirano, A., Manaka, H., Sasaki, H., Katagiri, T., Kawanami, T., Shikama, Y., Seino, T., & Sasaki, H. (1991). Calcitonin gene-related peptide immunoreactivity in familial amyotrophic lateral sclerosis. Neuroscience Letters, 133(2), 163-167. https://doi.org/10.1016/0304-3940(91)90560-G