Calcitonin gene-related peptide immunoreactivity in familial amyotrophic lateral sclerosis

Takeo Kato; Asao Hirano; Hideo Manaka; Hajime Sasaki; Tadashi Katagiri; Toru Kawanami; Yukihiro Shikama; Tomomi Seino; Hideo Sasaki

doi:10.1016/0304-3940(91)90560-G

Calcitonin gene-related peptide immunoreactivity in familial amyotrophic lateral sclerosis

Takeo Kato, Asao Hirano, Hideo Manaka, Hajime Sasaki, Tadashi Katagiri, Toru Kawanami, Yukihiro Shikama, Tomomi Seino, Hideo Sasaki

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The lumbar cords from 3 cases of familial amyotrophic lateral sclerosis (fALS), one case of vincristine neuropathy, and two control cases were examined with an antiserum to calcitonin gene-related peptide (CGRP). The anti-CGRP intensely labelled the spinal posterior horns in all cases. In the anterior horns, several perikarya and cord-like neuritic swellings, mostly axons, were labelled with the antibody in the fALS cases, whereas CGRP-positive structures were extremely rare in the cases other than fALS. It is possible that the accumulation of CGRP in the proximal axonal swellings and perikarya may result from entrapment of CGRP during the anterograde axonal transport, causing loss of, or decrease in, CGRP at the neuromuscular junction and producing weakness and atrophy of the muscles.

Original language	English (US)
Pages (from-to)	163-167
Number of pages	5
Journal	Neuroscience Letters
Volume	133
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(91)90560-G
State	Published - Dec 9 1991
Externally published	Yes

Keywords

Anterior horn cell
Calcitonin gene-related peptide
Central chromatolysis
Cord-like neuritic swelling
Familial amyotrophic lateral sclerosis
Neurofilament
Spinal cord
Ubiquitin

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(91)90560-G

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title = "Calcitonin gene-related peptide immunoreactivity in familial amyotrophic lateral sclerosis",

abstract = "The lumbar cords from 3 cases of familial amyotrophic lateral sclerosis (fALS), one case of vincristine neuropathy, and two control cases were examined with an antiserum to calcitonin gene-related peptide (CGRP). The anti-CGRP intensely labelled the spinal posterior horns in all cases. In the anterior horns, several perikarya and cord-like neuritic swellings, mostly axons, were labelled with the antibody in the fALS cases, whereas CGRP-positive structures were extremely rare in the cases other than fALS. It is possible that the accumulation of CGRP in the proximal axonal swellings and perikarya may result from entrapment of CGRP during the anterograde axonal transport, causing loss of, or decrease in, CGRP at the neuromuscular junction and producing weakness and atrophy of the muscles.",

keywords = "Anterior horn cell, Calcitonin gene-related peptide, Central chromatolysis, Cord-like neuritic swelling, Familial amyotrophic lateral sclerosis, Neurofilament, Spinal cord, Ubiquitin",

author = "Takeo Kato and Asao Hirano and Hideo Manaka and Hajime Sasaki and Tadashi Katagiri and Toru Kawanami and Yukihiro Shikama and Tomomi Seino and Hideo Sasaki",

year = "1991",

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doi = "10.1016/0304-3940(91)90560-G",

language = "English (US)",

volume = "133",

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AU - Kato, Takeo

AU - Hirano, Asao

AU - Manaka, Hideo

AU - Sasaki, Hajime

AU - Katagiri, Tadashi

AU - Kawanami, Toru

AU - Shikama, Yukihiro

AU - Seino, Tomomi

AU - Sasaki, Hideo

PY - 1991/12/9

Y1 - 1991/12/9

N2 - The lumbar cords from 3 cases of familial amyotrophic lateral sclerosis (fALS), one case of vincristine neuropathy, and two control cases were examined with an antiserum to calcitonin gene-related peptide (CGRP). The anti-CGRP intensely labelled the spinal posterior horns in all cases. In the anterior horns, several perikarya and cord-like neuritic swellings, mostly axons, were labelled with the antibody in the fALS cases, whereas CGRP-positive structures were extremely rare in the cases other than fALS. It is possible that the accumulation of CGRP in the proximal axonal swellings and perikarya may result from entrapment of CGRP during the anterograde axonal transport, causing loss of, or decrease in, CGRP at the neuromuscular junction and producing weakness and atrophy of the muscles.

AB - The lumbar cords from 3 cases of familial amyotrophic lateral sclerosis (fALS), one case of vincristine neuropathy, and two control cases were examined with an antiserum to calcitonin gene-related peptide (CGRP). The anti-CGRP intensely labelled the spinal posterior horns in all cases. In the anterior horns, several perikarya and cord-like neuritic swellings, mostly axons, were labelled with the antibody in the fALS cases, whereas CGRP-positive structures were extremely rare in the cases other than fALS. It is possible that the accumulation of CGRP in the proximal axonal swellings and perikarya may result from entrapment of CGRP during the anterograde axonal transport, causing loss of, or decrease in, CGRP at the neuromuscular junction and producing weakness and atrophy of the muscles.

KW - Anterior horn cell

KW - Calcitonin gene-related peptide

KW - Central chromatolysis

KW - Cord-like neuritic swelling

KW - Familial amyotrophic lateral sclerosis

KW - Neurofilament

KW - Spinal cord

KW - Ubiquitin

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DO - 10.1016/0304-3940(91)90560-G

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JO - Neuroscience Letters

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ER -

Calcitonin gene-related peptide immunoreactivity in familial amyotrophic lateral sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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