Abstract
Calciphylaxis, also called calcific uremic arteriolopathy is a dreadful, life-threatening ischemic vasculopathy, primarily involving skin and subcutaneous tissue, mostly on patients with end-stage kidney disease. Calciphylaxis is a well-described, but still a poorly understood disorder of mineral metabolism. Its occurrence is rare, but increasingly reported. We describe a 62-year-old obese lady on hemodialysis for end-stage kidney disease due to type 2 diabetes, who developed two episodes of calciphylactic skin lesions during the 3 years observation. The healing of lesions in the first episode was prompted by a subtotal parathyroidectomy for severe secondary hyperparathyroidism. However, the resumption of oral calcium and vitamin D analog for the parathyroidectomy-related hypocalcemia induced another occurrence of widespread calciphylactic skin lesions in areas of great adiposity. The typical regimen of IV sodium thiosulfate brought a successful outcome to the second episode. Now, growing numbers of successful treatment for calciphylaxis are reported with more specific therapies and a clear understanding of the pathogenetic mechanism is in sight.
Original language | English (US) |
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Pages (from-to) | S33-S36 |
Journal | Hemodialysis International |
Volume | 17 |
Issue number | SUPPL1 |
DOIs | |
State | Published - Oct 2013 |
Keywords
- Calciphylaxis
- End stage kidney disease
- Hemodialysis
- Hypocalcemia
- Parathyroidectomy
- Sodium thiosulfate
ASJC Scopus subject areas
- Hematology
- Nephrology