Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia

S. Goto, A. Hirano, J. Pearson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This report concerns the immunohistochemical demonstration of two neuronal Ca2+-binding proteins, calcineurin and synaptophysin, in the spinal cord of normal controls and from patients with familial dysautonomia. In controls, calcineurin immunoreactivity was highly concentrated in small nerve cells and fibers of the substantia gelatinosa. Synaptophysin immunoreactivity was normally distributed throughout the spinal cord gray matter, being highly concentrated in the substantia gelatinosa, the dorsal nucleus of Clarke and the anterior horn. In patients with familial dysautonomia, no apparent changes in calcineurin immunoreactivity were found in the substantia gelatinosa. By contrast, there was a significant depletion of synaptophysin-positive axon terminals in the substantia gelatinosa and in the dorsal nucleus of Clarke of patients with familial dysautonomia.

Original languageEnglish (US)
Pages (from-to)647-652
Number of pages6
JournalActa Neuropathologica
Volume79
Issue number6
DOIs
StatePublished - Apr 1990

Fingerprint

Familial Dysautonomia
Substantia Gelatinosa
Synaptophysin
Calcineurin
Spinal Cord
Presynaptic Terminals
Horns
Nerve Fibers
Carrier Proteins
Neurons

Keywords

  • Calcineurin
  • Familial dysautonomia
  • Spinal cord
  • Substantia gelatinosa
  • Synaptophysin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia. / Goto, S.; Hirano, A.; Pearson, J.

In: Acta Neuropathologica, Vol. 79, No. 6, 04.1990, p. 647-652.

Research output: Contribution to journalArticle

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