Calcineurin, a calcium/calmodulin-regulated protein phosphatase, in mammalian neuroendocrine cells and neoplasms

Satoshi Goto, Shinji Nagahiro, Yukitaka Ushio, Asao Hirano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Calcineurin is a calcium/calmodulin-regulated protein phosphatase. By using enzyme-immunoassay and immunocytochemistry with an affinity-purified specific antibody to this protein, we have found that calcineurin is expressed in the central and peripheral neuroendocrine cells, also termed amine precursor uptake and decarboxylation cells. In addition, calcineurin immunoreactivity was found in the central neuroendocrine neoplasms such as pineocytoma, olfactory neuroblastoma and paraganglioma. The present findings indicate that the activity of phosphatase regulated by calcium and calmodulin is involved in neuroendocrine functions, and that the enzyme can be useful for the identification and characterization of neuroendocrine cell tumors.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalNeuroscience Letters
Volume143
Issue number1-2
DOIs
StatePublished - Aug 31 1992

Fingerprint

Neuroendocrine Cells
Calcineurin
Phosphoprotein Phosphatases
Calmodulin
Calcium
APUD Cells
Olfactory Esthesioneuroblastoma
Pinealoma
Paraganglioma
Neoplasms
Neuroendocrine Tumors
Immunoenzyme Techniques
Phosphoric Monoester Hydrolases
Immunohistochemistry
Antibodies
Enzymes
Proteins

Keywords

  • Calcineurin
  • Calcium
  • Calmodulin
  • Enzyme-immunoassay
  • Immunocytochemistry
  • Neuroendocrine cell

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Calcineurin, a calcium/calmodulin-regulated protein phosphatase, in mammalian neuroendocrine cells and neoplasms. / Goto, Satoshi; Nagahiro, Shinji; Ushio, Yukitaka; Hirano, Asao.

In: Neuroscience Letters, Vol. 143, No. 1-2, 31.08.1992, p. 51-54.

Research output: Contribution to journalArticle

Goto, Satoshi ; Nagahiro, Shinji ; Ushio, Yukitaka ; Hirano, Asao. / Calcineurin, a calcium/calmodulin-regulated protein phosphatase, in mammalian neuroendocrine cells and neoplasms. In: Neuroscience Letters. 1992 ; Vol. 143, No. 1-2. pp. 51-54.
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