Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex

Hong Zhang, Scott W. Emmons

Research output: Contribution to journalArticle

25 Scopus citations


Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.

Original languageEnglish (US)
Pages (from-to)799-803
Number of pages5
Issue number2
Publication statusPublished - Mar 14 2002


ASJC Scopus subject areas

  • Genetics

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