Caenorhabditis elegans and its applicability to studies on RLS

Pan Chen, Omamuyovwi Meashack Ijomone, Kun He Lee, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Restless legs syndrome (RLS) is a common neurological disorder in the United States. This disorder is characterized by an irresistible urge to move the legs, although the symptoms vary in a wide range. The pathobiology of RLS has been linked to iron (Fe) deficiency and dopaminergic (DAergic) dysfunction. Several genetic factors have been reported to increase the risk of RLS. Caenorhabditis elegans (C. elegans) is a well-established animal model with a fully sequenced genome, which is highly conserved with mammals. Given the detailed knowledge of its genomic architecture, ease of genetic manipulation and conserved biosynthetic and metabolic pathways, as well as its small size, ease of maintenance, speedy generation time and large brood size, C. elegans provides numerous advantages in studying RLS-associated gene-environment interactions. Here we will review current knowledge about RLS symptoms, pathology and treatments, and discuss the application of C. elegans in RLS study, including the worm homologous genes and methods that could be performed to advance the pathophysiology RLS.

Original languageEnglish (US)
Title of host publicationAdvances in Pharmacology
PublisherAcademic Press Inc.
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Pharmacology
ISSN (Print)1054-3589
ISSN (Electronic)1557-8925

Fingerprint

Restless Legs Syndrome
Caenorhabditis elegans
Gene-Environment Interaction
Biosynthetic Pathways
Metabolic Networks and Pathways
Nervous System Diseases
Mammals
Leg
Iron
Animal Models
Maintenance
Genome
Pathology
Genes

Keywords

  • C. elegans
  • Dopaminergic dysfunction
  • Iron deficiency
  • Restless legs syndrome
  • RLS

ASJC Scopus subject areas

  • Pharmacology

Cite this

Chen, P., Ijomone, O. M., Lee, K. H., & Aschner, M. (2019). Caenorhabditis elegans and its applicability to studies on RLS. In Advances in Pharmacology (Advances in Pharmacology). Academic Press Inc.. https://doi.org/10.1016/bs.apha.2018.12.003

Caenorhabditis elegans and its applicability to studies on RLS. / Chen, Pan; Ijomone, Omamuyovwi Meashack; Lee, Kun He; Aschner, Michael.

Advances in Pharmacology. Academic Press Inc., 2019. (Advances in Pharmacology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Chen, P, Ijomone, OM, Lee, KH & Aschner, M 2019, Caenorhabditis elegans and its applicability to studies on RLS. in Advances in Pharmacology. Advances in Pharmacology, Academic Press Inc. https://doi.org/10.1016/bs.apha.2018.12.003
Chen P, Ijomone OM, Lee KH, Aschner M. Caenorhabditis elegans and its applicability to studies on RLS. In Advances in Pharmacology. Academic Press Inc. 2019. (Advances in Pharmacology). https://doi.org/10.1016/bs.apha.2018.12.003
Chen, Pan ; Ijomone, Omamuyovwi Meashack ; Lee, Kun He ; Aschner, Michael. / Caenorhabditis elegans and its applicability to studies on RLS. Advances in Pharmacology. Academic Press Inc., 2019. (Advances in Pharmacology).
@inbook{4601e55250bb4e63a3e3023c8944b51b,
title = "Caenorhabditis elegans and its applicability to studies on RLS",
abstract = "Restless legs syndrome (RLS) is a common neurological disorder in the United States. This disorder is characterized by an irresistible urge to move the legs, although the symptoms vary in a wide range. The pathobiology of RLS has been linked to iron (Fe) deficiency and dopaminergic (DAergic) dysfunction. Several genetic factors have been reported to increase the risk of RLS. Caenorhabditis elegans (C. elegans) is a well-established animal model with a fully sequenced genome, which is highly conserved with mammals. Given the detailed knowledge of its genomic architecture, ease of genetic manipulation and conserved biosynthetic and metabolic pathways, as well as its small size, ease of maintenance, speedy generation time and large brood size, C. elegans provides numerous advantages in studying RLS-associated gene-environment interactions. Here we will review current knowledge about RLS symptoms, pathology and treatments, and discuss the application of C. elegans in RLS study, including the worm homologous genes and methods that could be performed to advance the pathophysiology RLS.",
keywords = "C. elegans, Dopaminergic dysfunction, Iron deficiency, Restless legs syndrome, RLS",
author = "Pan Chen and Ijomone, {Omamuyovwi Meashack} and Lee, {Kun He} and Michael Aschner",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/bs.apha.2018.12.003",
language = "English (US)",
series = "Advances in Pharmacology",
publisher = "Academic Press Inc.",
booktitle = "Advances in Pharmacology",
address = "United States",

}

TY - CHAP

T1 - Caenorhabditis elegans and its applicability to studies on RLS

AU - Chen, Pan

AU - Ijomone, Omamuyovwi Meashack

AU - Lee, Kun He

AU - Aschner, Michael

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Restless legs syndrome (RLS) is a common neurological disorder in the United States. This disorder is characterized by an irresistible urge to move the legs, although the symptoms vary in a wide range. The pathobiology of RLS has been linked to iron (Fe) deficiency and dopaminergic (DAergic) dysfunction. Several genetic factors have been reported to increase the risk of RLS. Caenorhabditis elegans (C. elegans) is a well-established animal model with a fully sequenced genome, which is highly conserved with mammals. Given the detailed knowledge of its genomic architecture, ease of genetic manipulation and conserved biosynthetic and metabolic pathways, as well as its small size, ease of maintenance, speedy generation time and large brood size, C. elegans provides numerous advantages in studying RLS-associated gene-environment interactions. Here we will review current knowledge about RLS symptoms, pathology and treatments, and discuss the application of C. elegans in RLS study, including the worm homologous genes and methods that could be performed to advance the pathophysiology RLS.

AB - Restless legs syndrome (RLS) is a common neurological disorder in the United States. This disorder is characterized by an irresistible urge to move the legs, although the symptoms vary in a wide range. The pathobiology of RLS has been linked to iron (Fe) deficiency and dopaminergic (DAergic) dysfunction. Several genetic factors have been reported to increase the risk of RLS. Caenorhabditis elegans (C. elegans) is a well-established animal model with a fully sequenced genome, which is highly conserved with mammals. Given the detailed knowledge of its genomic architecture, ease of genetic manipulation and conserved biosynthetic and metabolic pathways, as well as its small size, ease of maintenance, speedy generation time and large brood size, C. elegans provides numerous advantages in studying RLS-associated gene-environment interactions. Here we will review current knowledge about RLS symptoms, pathology and treatments, and discuss the application of C. elegans in RLS study, including the worm homologous genes and methods that could be performed to advance the pathophysiology RLS.

KW - C. elegans

KW - Dopaminergic dysfunction

KW - Iron deficiency

KW - Restless legs syndrome

KW - RLS

UR - http://www.scopus.com/inward/record.url?scp=85062805789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062805789&partnerID=8YFLogxK

U2 - 10.1016/bs.apha.2018.12.003

DO - 10.1016/bs.apha.2018.12.003

M3 - Chapter

T3 - Advances in Pharmacology

BT - Advances in Pharmacology

PB - Academic Press Inc.

ER -