Cadherins and catenins in clival chordomas: Correlation of expression with tumor aggressiveness

Aymara Triana, Chandranath Sen, David Wolfe, Rachel Hazan

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The local invasiveness and occasional rapid growth of chordomas, despite optimal treatment, highlight the need to develop ways to predict their biologic behavior. Alterations in adhesion proteins have been shown to participate in proliferation, invasiveness, and metastasis in epithelial tumors. We therefore analyzed the expression of E-cadherin, N-cadherin, as well as their cytosolic binding proteins α-catenin, β-catenin, and γ-catenin, in 51 paraffin archived and 17 cryopreserved chordoma specimens. In the majority of chordomas, E-cadherin and N-cadherin expression was inversely correlated, whereas β-catenin and γ-catenin expression was directly correlated. By multivariate analysis, N-cadherin up-regulation correlated with a diminished recurrence-free survival, and E-cadherin down-regulation strongly correlated with increased probabilities of death as determined by the Kaplan-Meier log-rank test. There was a 3.28-fold increased probability of having a tumor recurrence and a 10.98-fold increased probability of dying when, respectively, N-cadherin was up-regulated and E-cadherin down-regulated. These results suggest that changes in the relative expression of the cadherin-catenin complex reflect chordoma aggressiveness; and that decreased expression of E-cadherin and increased expression of N-cadherin may underlie the transition from a less to a more aggressive tumor phenotype.

Original languageEnglish (US)
Pages (from-to)1422-1434
Number of pages13
JournalAmerican Journal of Surgical Pathology
Volume29
Issue number11
DOIs
StatePublished - Nov 2005

Keywords

  • Aggressiveness
  • Cadherin
  • Catenins
  • Chordoma
  • Expression

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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