Cadherin switch in tumor progression

Rachel Hazan, Rui Qiao, Rinat Keren, Ines Badano, Kimita Suyama

Research output: Contribution to journalArticle

409 Citations (Scopus)

Abstract

The loss of E-cadherin expression or function in epithelial carcinomas has long been thought as a primary reason for disruption of tight epithelial cell-cell contacts and release of invasive tumor cells from the primary tumor. Indeed, E-cadherin serves as a widely acting suppressor of invasion and growth of epithelial cancers, and its functional elimination represents a key step in the acquisition of the invasive phenotype for many tumors. Recent evidence indicates, however, that in addition to the loss of the "invasion- suppressor" E-cadherin, another adhesion molecule, N-cadherin, becomes upregulated in invasive tumor cell lines. N-cadherin was shown to be present in the most invasive and dedifferentiated breast cancer cell lines, and its exogenous expression in tumor cells induces a scattered morphology and heightened motility, invasion, and metastasis. N-cadherin cooperates with the FGF receptor, resulting in signals that lead to the up-modulation of MMP-9 and, hence, cellular invasion. In addition to a signaling function in metastasis, N-cadherin probably also supports the systemic dissemination of tumor cells by enabling circulating tumor cells to associate with the stroma and the endothelium at distant sites. Here, we summarize the various aspects of the E- to N-cadherin switching in epithelial carcinomas and its potential impact on metastatic progression.

Original languageEnglish (US)
Pages (from-to)155-163
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume1014
DOIs
StatePublished - 2004

Fingerprint

Cadherins
Tumors
Switches
Cells
Neoplasms
Neoplasm Metastasis
Carcinoma
Circulating Neoplastic Cells
Fibroblast Growth Factor Receptors
Progression
Tumor Cell Line
Matrix Metalloproteinases
Endothelium
Adhesion
Epithelial Cells
Modulation
Breast Neoplasms
Phenotype
Cell Line
Molecules

Keywords

  • Adhesion
  • Cadherin
  • Carcinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cadherin switch in tumor progression. / Hazan, Rachel; Qiao, Rui; Keren, Rinat; Badano, Ines; Suyama, Kimita.

In: Annals of the New York Academy of Sciences, Vol. 1014, 2004, p. 155-163.

Research output: Contribution to journalArticle

Hazan, Rachel ; Qiao, Rui ; Keren, Rinat ; Badano, Ines ; Suyama, Kimita. / Cadherin switch in tumor progression. In: Annals of the New York Academy of Sciences. 2004 ; Vol. 1014. pp. 155-163.
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