C. elegans—an emerging model to study metal-induced rage-related pathologies

Adi Pinkas, Airton Cunha Martins, Michael Aschner

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, C. elegans has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.

Original languageEnglish (US)
Article number1407
JournalInternational journal of environmental research and public health
Volume15
Issue number7
DOIs
Publication statusPublished - Jul 4 2018

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Keywords

  • Arsenic
  • C Elegans
  • Manganese
  • Methylmercury
  • Receptor for advanced glycation end products
  • Selenium
  • Zinc

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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