BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia

Caridad López-Granero, Alessandra Antunes dos Santos, Beatriz Ferrer, Megan Culbreth, Sudipta Chakraborty, Angel Barrasa, Maria Gulinello, Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Depression and anxiety are the most common psychiatric disorders, representing a major public health concern. Dysregulation of oxidative and inflammatory systems may be associated with psychiatric disorders, such as depression and anxiety. Due to the need to find appropriate animal models to the understanding of such disorders, we queried whether 2 BXD recombinant inbred (RI) mice strains (BXD21/TyJ RI and BXD84/RwwJ RI mice) and C57BL/6 wild-type mice show differential performance in depression and anxiety related behaviors and biomarkers. Specifically, we assessed social preference, elevated plus maze, forced swim, and Von Frey tests at 3–4 months-of-age, as well as activation of cytokines and antioxidant mRNA levels in the cortex at 7 months-of-age. We report that (1) the BXD84/RwwJ RI strain exhibits anxiety disorder and social avoidance-like behavior (2) BXD21/TyJ RI strain shows a resistance to depression illness, and (3) sex-dependent cytokine profiles and allodynia with elevated inflammatory activity were inherent to male BXD21/TyJ RI mice. In conclusion, we provide novel data in favor of the use of BXD recombinant inbred mice to further understand anxiety and depression disorders.

Original languageEnglish (US)
Pages (from-to)92-98
Number of pages7
JournalPsychoneuroendocrinology
Volume80
DOIs
StatePublished - Jun 1 2017

Fingerprint

Hyperalgesia
Sex Characteristics
Anxiety
Depression
Cytokines
Psychiatry
Avoidance Learning
Inbred Strains Mice
Anxiety Disorders
Inbred C57BL Mouse
Animal Models
Public Health
Antioxidants
Biomarkers
Messenger RNA

Keywords

  • Anxiety
  • BXD RI mice
  • Cytokines
  • Depression
  • Inflammation
  • Nrf2

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia. / López-Granero, Caridad; Antunes dos Santos, Alessandra; Ferrer, Beatriz; Culbreth, Megan; Chakraborty, Sudipta; Barrasa, Angel; Gulinello, Maria; Bowman, Aaron B.; Aschner, Michael.

In: Psychoneuroendocrinology, Vol. 80, 01.06.2017, p. 92-98.

Research output: Contribution to journalArticle

López-Granero, Caridad ; Antunes dos Santos, Alessandra ; Ferrer, Beatriz ; Culbreth, Megan ; Chakraborty, Sudipta ; Barrasa, Angel ; Gulinello, Maria ; Bowman, Aaron B. ; Aschner, Michael. / BXD recombinant inbred strains participate in social preference, anxiety and depression behaviors along sex-differences in cytokines and tactile allodynia. In: Psychoneuroendocrinology. 2017 ; Vol. 80. pp. 92-98.
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