Bxd recombinant inbred mice as a model to study neurotoxicity

Airton C. Martins; Caridad López-Granero; Beatriz Ferrer; Alexey A. Tinkov; Anatoly V. Skalny; Monica M.B. Paoliello; Michael Aschner

doi:10.3390/biom11121762

Bxd recombinant inbred mice as a model to study neurotoxicity

Airton C. Martins, Caridad López-Granero, Beatriz Ferrer, Alexey A. Tinkov, Anatoly V. Skalny, Monica M.B. Paoliello, Michael Aschner

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.

Original language	English (US)
Article number	1762
Journal	Biomolecules
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/biom11121762
State	Published - Dec 2021

Keywords

Alcohol
Cocaine
Genetic
Metals
Pesticides

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/biom11121762

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title = "Bxd recombinant inbred mice as a model to study neurotoxicity",

abstract = "BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.",

keywords = "Alcohol, Cocaine, Genetic, Metals, Pesticides",

author = "Martins, {Airton C.} and Caridad L{\'o}pez-Granero and Beatriz Ferrer and Tinkov, {Alexey A.} and Skalny, {Anatoly V.} and Paoliello, {Monica M.B.} and Michael Aschner",

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year = "2021",

month = dec,

doi = "10.3390/biom11121762",

language = "English (US)",

volume = "11",

journal = "Biomolecules",

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T1 - Bxd recombinant inbred mice as a model to study neurotoxicity

AU - Martins, Airton C.

AU - López-Granero, Caridad

AU - Ferrer, Beatriz

AU - Tinkov, Alexey A.

AU - Skalny, Anatoly V.

AU - Paoliello, Monica M.B.

AU - Aschner, Michael

PY - 2021/12

Y1 - 2021/12

N2 - BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.

AB - BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.

KW - Alcohol

KW - Cocaine

KW - Genetic

KW - Metals

KW - Pesticides

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U2 - 10.3390/biom11121762

DO - 10.3390/biom11121762

M3 - Review article

C2 - 34944406

AN - SCOPUS:85119664009

SN - 2218-273X

VL - 11

JO - Biomolecules

JF - Biomolecules

IS - 12

M1 - 1762

ER -

Bxd recombinant inbred mice as a model to study neurotoxicity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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