TY - JOUR
T1 - Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells
AU - Maier, Sandra
AU - Daroqui, M. Cecilia
AU - Scherer, Stefan
AU - Roepcke, Stefan
AU - Velcich, Anna
AU - Shenoy, Shailesh M.
AU - Singer, Robert H.
AU - Augenlicht, Leonard H.
PY - 2009/3
Y1 - 2009/3
N2 - In stimulating maturation of colonic carcinoma cells, the short chain fatty acid butyrate, and 1α,25-dihydroxyvitamin D3, were shown to attenuate transcription of the cyclin D1 gene, giving rise to truncated transcripts of this locus. Moreover, a sequence which is highly conserved in the human, mouse, rat, and dog genome was found in the 4 kb long intron 3 of the human cyclin D1 gene, and is capable of forming a hairpin structure similar to that of microRNA precursors. The expression of this sequence is also decreased by the attenuation. Thus, the transcriptional attenuation at the cyclin D1 locus not only down-regulates the expression of this key gene in mucosal cell maturation and tumorigenesis, but may also abrogate the generation of a molecule that encompasses this conserved sequence in cyclin D1 intron 3.
AB - In stimulating maturation of colonic carcinoma cells, the short chain fatty acid butyrate, and 1α,25-dihydroxyvitamin D3, were shown to attenuate transcription of the cyclin D1 gene, giving rise to truncated transcripts of this locus. Moreover, a sequence which is highly conserved in the human, mouse, rat, and dog genome was found in the 4 kb long intron 3 of the human cyclin D1 gene, and is capable of forming a hairpin structure similar to that of microRNA precursors. The expression of this sequence is also decreased by the attenuation. Thus, the transcriptional attenuation at the cyclin D1 locus not only down-regulates the expression of this key gene in mucosal cell maturation and tumorigenesis, but may also abrogate the generation of a molecule that encompasses this conserved sequence in cyclin D1 intron 3.
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U2 - 10.1002/jcp.21642
DO - 10.1002/jcp.21642
M3 - Article
C2 - 19034928
AN - SCOPUS:58149375066
SN - 0021-9541
VL - 218
SP - 638
EP - 642
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 3
ER -