Burden of prematurity-associated recurrent wheezing: caregiver missed work in the D-Wheeze trial

Lauren Ledingham; Curtis Tatsuoka; Nori Minich; Kristie R. Ross; Leigh Ann Kerns; Carol L. Wagner; Mamta Fuloria; Sharon Groh-Wargo; Teresa Zimmerman; Anna Maria Hibbs

doi:10.1038/s41372-020-0729-7

Burden of prematurity-associated recurrent wheezing: caregiver missed work in the D-Wheeze trial

Lauren Ledingham, Curtis Tatsuoka, Nori Minich, Kristie R. Ross, Leigh Ann Kerns, Carol L. Wagner, Mamta Fuloria, Sharon Groh-Wargo, Teresa Zimmerman, Anna Maria Hibbs

Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: This study describes the burden of prematurity-associated wheezing in black infants with respect to caregiver missed work. Study design: We analyzed data from the D-Wheeze trial (ClinicalTrials.gov identifier NCT01601847). Black infants between 28–0/7 to 36–6/7 weeks’ gestational age at birth receiving <28 days of supplemental oxygen were enrolled. The primary outcome was missed work to care for the infant in the first year. Results: 147/277 (53.1%) infants had caregivers who reported time off. In an adjusted model, vitamin D supplementation (OR 0.52 [95% CI 0.30–0.89]; P = 0.018), recurrent wheeze (OR 2.26 [95% CI, 1.15–4.44]; P = 0.018), and other children in the household <5 years old (OR 0.45 [95% CI 0.26–0.78]; P = 0.004) were significantly associated with caregiver missed work. Conclusions: Black premature infants had a significant burden of caregiver missed work, emphasizing the impact of prematurity-associated wheezing.

Original language	English (US)
Pages (from-to)	69-76
Number of pages	8
Journal	Journal of Perinatology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1038/s41372-020-0729-7
State	Published - Jan 2021

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-020-0729-7

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title = "Burden of prematurity-associated recurrent wheezing: caregiver missed work in the D-Wheeze trial",

abstract = "Objective: This study describes the burden of prematurity-associated wheezing in black infants with respect to caregiver missed work. Study design: We analyzed data from the D-Wheeze trial (ClinicalTrials.gov identifier NCT01601847). Black infants between 28–0/7 to 36–6/7 weeks{\textquoteright} gestational age at birth receiving <28 days of supplemental oxygen were enrolled. The primary outcome was missed work to care for the infant in the first year. Results: 147/277 (53.1%) infants had caregivers who reported time off. In an adjusted model, vitamin D supplementation (OR 0.52 [95% CI 0.30–0.89]; P = 0.018), recurrent wheeze (OR 2.26 [95% CI, 1.15–4.44]; P = 0.018), and other children in the household <5 years old (OR 0.45 [95% CI 0.26–0.78]; P = 0.004) were significantly associated with caregiver missed work. Conclusions: Black premature infants had a significant burden of caregiver missed work, emphasizing the impact of prematurity-associated wheezing.",

author = "Lauren Ledingham and Curtis Tatsuoka and Nori Minich and Ross, {Kristie R.} and Kerns, {Leigh Ann} and Wagner, {Carol L.} and Mamta Fuloria and Sharon Groh-Wargo and Teresa Zimmerman and Hibbs, {Anna Maria}",

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year = "2021",

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doi = "10.1038/s41372-020-0729-7",

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T2 - caregiver missed work in the D-Wheeze trial

AU - Ledingham, Lauren

AU - Tatsuoka, Curtis

AU - Minich, Nori

AU - Ross, Kristie R.

AU - Kerns, Leigh Ann

AU - Wagner, Carol L.

AU - Fuloria, Mamta

AU - Groh-Wargo, Sharon

AU - Zimmerman, Teresa

AU - Hibbs, Anna Maria

PY - 2021/1

Y1 - 2021/1

N2 - Objective: This study describes the burden of prematurity-associated wheezing in black infants with respect to caregiver missed work. Study design: We analyzed data from the D-Wheeze trial (ClinicalTrials.gov identifier NCT01601847). Black infants between 28–0/7 to 36–6/7 weeks’ gestational age at birth receiving <28 days of supplemental oxygen were enrolled. The primary outcome was missed work to care for the infant in the first year. Results: 147/277 (53.1%) infants had caregivers who reported time off. In an adjusted model, vitamin D supplementation (OR 0.52 [95% CI 0.30–0.89]; P = 0.018), recurrent wheeze (OR 2.26 [95% CI, 1.15–4.44]; P = 0.018), and other children in the household <5 years old (OR 0.45 [95% CI 0.26–0.78]; P = 0.004) were significantly associated with caregiver missed work. Conclusions: Black premature infants had a significant burden of caregiver missed work, emphasizing the impact of prematurity-associated wheezing.

AB - Objective: This study describes the burden of prematurity-associated wheezing in black infants with respect to caregiver missed work. Study design: We analyzed data from the D-Wheeze trial (ClinicalTrials.gov identifier NCT01601847). Black infants between 28–0/7 to 36–6/7 weeks’ gestational age at birth receiving <28 days of supplemental oxygen were enrolled. The primary outcome was missed work to care for the infant in the first year. Results: 147/277 (53.1%) infants had caregivers who reported time off. In an adjusted model, vitamin D supplementation (OR 0.52 [95% CI 0.30–0.89]; P = 0.018), recurrent wheeze (OR 2.26 [95% CI, 1.15–4.44]; P = 0.018), and other children in the household <5 years old (OR 0.45 [95% CI 0.26–0.78]; P = 0.004) were significantly associated with caregiver missed work. Conclusions: Black premature infants had a significant burden of caregiver missed work, emphasizing the impact of prematurity-associated wheezing.

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Burden of prematurity-associated recurrent wheezing: caregiver missed work in the D-Wheeze trial

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