Buprenorphine treatment outcomes among opioid-dependent cocaine users and non-users

Chinazo O. Cunningham, Angela Giovanniello, Hillary V. Kunins, Robert J. Roose, Aaron D. Fox, Nancy L. Sohler

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and Objectives: National treatment guidelines state that polysubstance users, including cocaine users, may not be appropriate candidates for office-based buprenorphine treatment. However, data to support this recommendation are sparse and conflicting, and the implications of this recommendation may include limiting the usefulness of buprenorphine treatment, as cocaine use is common among opioid-dependent individuals seeking buprenorphine treatment. We compared buprenorphine treatment outcomes (6-month treatment retention and self-reported opioid use over 6 months) in opioid-dependent cocaine users versus non-users who initiated buprenorphine treatment at an urban community health center. Methods: We followed 87 participants over 6 months, collecting interview and medical record data. We used logistic regression models to test whether baseline cocaine use was associated with treatment retention and mixed effects nonlinear models to test whether baseline cocaine use was associated with self-reported opioid use. Results: At baseline, 39.1% reported cocaine use. In all participants, self-reported opioid use decreased from 89.7% to 27.4% over 6 months, and 6-month treatment retention was 54.5%. We found no significant difference in 6-month treatment retention (AOR = 1.56, 95% CI:.58-4.17, p =.38) or self-reported opioid use (AOR =.89, 95% CI:.26-3.07, p =.85) between cocaine users and non-users. Conclusions: and Scientific Significance This study demonstrates that buprenorphine treatment retention is not worse in cocaine users than non-users, with clinically meaningful improvements in self-reported opioid use. These findings suggest that opioid-dependent cocaine users attain considerable benefits from office-based buprenorphine treatment and argue for the inclusion of these patients in office-based buprenorphine treatment programs.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalAmerican Journal on Addictions
Volume22
Issue number4
DOIs
StatePublished - Jul 2013

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Buprenorphine
Cocaine
Opioid Analgesics
Therapeutics
Logistic Models
Urban Health
Community Health Centers
Nonlinear Dynamics
Medical Records
Guidelines
Interviews

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Buprenorphine treatment outcomes among opioid-dependent cocaine users and non-users. / Cunningham, Chinazo O.; Giovanniello, Angela; Kunins, Hillary V.; Roose, Robert J.; Fox, Aaron D.; Sohler, Nancy L.

In: American Journal on Addictions, Vol. 22, No. 4, 07.2013, p. 352-357.

Research output: Contribution to journalArticle

Cunningham, Chinazo O. ; Giovanniello, Angela ; Kunins, Hillary V. ; Roose, Robert J. ; Fox, Aaron D. ; Sohler, Nancy L. / Buprenorphine treatment outcomes among opioid-dependent cocaine users and non-users. In: American Journal on Addictions. 2013 ; Vol. 22, No. 4. pp. 352-357.
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