Bullous pemphigoid after liver transplantation for liver failure

Nanda Kerkar, Steven R. Cohen, Christina Dugan, Raffaella A. Morotti, Robert G. Phelps, Betsy Herold, Benjamin Shneider, Sukru Emre

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Coomb's positive autoimmune hemolytic anemia with giant cell hepatitis (GCH) is a rare cause of liver failure and is usually associated with poor prognosis. A child with liver kidney microsomal (LKM) antibody positivity underwent successful liver transplantation for liver failure secondary to GCH with Coomb's positive hemolytic anemia. Autoimmune neutropenia developed ten months after transplant. Four months later, pemphigoid skin lesions developed. The diagnosis of bullous pemphigoid (BP) was made on the basis of skin biopsy, direct and indirect immunofluorescence test results. Treatment was with immunosuppressants - prednisone and azathioprine/rapamycin, with addition of dapsone when lesions persisted. This child is unique in that his liver function and hemolytic anemia appeared to normalize after liver transplant, but neutropenia and BP both thought to be autoimmune in etiology, developed more than a year post-transplant.

Original languageEnglish (US)
Pages (from-to)1705-1710
Number of pages6
JournalLiver Transplantation
Volume12
Issue number11
DOIs
StatePublished - Nov 2006

Fingerprint

Bullous Pemphigoid
Liver Failure
Liver Transplantation
Hemolytic Anemia
Giant Cells
Neutropenia
Transplants
Hepatitis
Liver
Autoimmune Hemolytic Anemia
Dapsone
Direct Fluorescent Antibody Technique
Skin
Azathioprine
Sirolimus
Immunosuppressive Agents
Indirect Fluorescent Antibody Technique
Prednisone
Kidney
Biopsy

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Kerkar, N., Cohen, S. R., Dugan, C., Morotti, R. A., Phelps, R. G., Herold, B., ... Emre, S. (2006). Bullous pemphigoid after liver transplantation for liver failure. Liver Transplantation, 12(11), 1705-1710. https://doi.org/10.1002/lt.20930

Bullous pemphigoid after liver transplantation for liver failure. / Kerkar, Nanda; Cohen, Steven R.; Dugan, Christina; Morotti, Raffaella A.; Phelps, Robert G.; Herold, Betsy; Shneider, Benjamin; Emre, Sukru.

In: Liver Transplantation, Vol. 12, No. 11, 11.2006, p. 1705-1710.

Research output: Contribution to journalArticle

Kerkar, N, Cohen, SR, Dugan, C, Morotti, RA, Phelps, RG, Herold, B, Shneider, B & Emre, S 2006, 'Bullous pemphigoid after liver transplantation for liver failure', Liver Transplantation, vol. 12, no. 11, pp. 1705-1710. https://doi.org/10.1002/lt.20930
Kerkar, Nanda ; Cohen, Steven R. ; Dugan, Christina ; Morotti, Raffaella A. ; Phelps, Robert G. ; Herold, Betsy ; Shneider, Benjamin ; Emre, Sukru. / Bullous pemphigoid after liver transplantation for liver failure. In: Liver Transplantation. 2006 ; Vol. 12, No. 11. pp. 1705-1710.
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