Bulk magnetic susceptibility effects on the assessment of intra- and extramyocellular lipids in vivo

Lidia S. Szczepaniak, Robert L. Dobbins, Daniel T. Stein, J. Denis McGarry

Research output: Contribution to journalArticle

60 Scopus citations


Localized proton spectroscopy provides a novel method for noninvasive measurement of lipid content in skeletal muscle. It has been suggested that the chemical shift difference between lipid signals from distinct compartments in skeletal muscle might be caused by bulk magnetic susceptibility (BMS) differences from lipids stored in intra- (IMCL) and extramyocellular (EMCL) compartments. Direct evidence is provided to confirm the theoretical prediction that compartment symmetry is responsible for discrimination between resonances of IMCL and EMCL. Phantoms imitating lipids in skeletal muscle were constructed using soybean oil to represent EMCL, and Intralipid™, an intravenous fat emulsion of fine droplets, to represent IMCL. It was found that the chemical shift of Intralipid™ is independent of the BMS effects, while the resonance of soybean oil shifts in a predictable manner determined by the geometry of the compartment.

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalMagnetic Resonance in Medicine
Issue number3
StatePublished - Mar 14 2002



  • Bulk magnetic susceptibility
  • Myocellular lipids
  • Proton spectroscopy
  • Skeletal muscle
  • Triglycerides

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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